Prognostic relevance of Tiam1 protein expression in prostate carcinomas.
Prognostic relevance of Tiam1 protein expression in prostate carcinomas.
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DOI：
10.1038/sj.bjc.6603385
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发表时间：
2006-10-23
影响因子：
8.8
通讯作者：
中科院分区：
文献类型：
--
作者：
Rac特异性鸟嘌呤核苷酸交换因子Tiam 1在致癌性、肿瘤侵袭和转移中起主要作用，但其作为人类癌症预后标志物的有用性尚未得到测试。在本研究中，Tiam 1的表达进行了分析，良性分泌上皮，癌前高级别前列腺上皮内瘤变（HG-PIN）和前列腺癌的60个R 0切除根治性前列腺切除术标本的半定量免疫组化。与良性分泌上皮相比，Tiam 1在HG-PIN（P<0.001）和前列腺癌（P<0.001）中均显著过表达。相对于相应的良性前列腺上皮，前列腺癌中的Tiam 1强过表达（即，10.35倍）与疾病复发（P=0.016）、淋巴管浸润（P=0.031）和高Gleason评分（GS）（即，10.77）（P=0.044）在统计学上显著相关。单变量分析显示，Tiam 1强过表达与无病生存期（DFS）降低存在统计学显著相关性（P=0.03）。在包括术前前列腺特异性抗原水平、pT分期和GS的多变量分析中，Tiam 1强过表达的预后作用仍然显著（相对风险= 3.75，95%置信区间=1.06-13.16; P=0.04）。总之，我们的数据表明，相对于相应的良性上皮细胞，Tiam 1的强过表达是前列腺癌患者DFS降低的一个新的独立预测因子。
The Rac-specific guanine nucleotide exchange factor, Tiam1, plays a major role in oncogenicity, tumour invasion and metastasis but its usefulness as a prognostic marker in human cancer has not been tested yet. In the present study, Tiam1 expression was analysed in benign secretory epithelium, pre-neoplastic high-grade prostatic intraepithelium neoplasia (HG-PIN) and prostate carcinomas of 60 R0-resected radical prostatectomy specimens by semiquantitative immunohistochemistry. Tiam1 proved significantly overexpressed in both HG-PIN (P<0.001) and prostate carcinomas (P<0.001) when compared to benign secretory epithelium. Strong Tiam1 overexpression (i.e. ⩾3.5-fold) in prostate carcinomas relative to the respective benign prostatic epithelium was statistically significantly associated with disease recurrence (P=0.016), the presence of lymph vessel invasion (P=0.031) and high Gleason scores (GS) (i.e. ⩾7) (P=0.044). Univariate analysis showed a statistically significant association of strong Tiam1 overexpression with decreased disease-free survival (DFS) (P=0.03). This prognostic effect of strong Tiam1 overexpression remained significant in multivariate analysis including preoperative prostate-specific antigen levels, pT stage, and GS (relative risk= 3.75, 95% confidence interval=1.06–13.16; P=0.04). Together, our data suggest that strong Tiam1 overexpression relative to the corresponding benign epithelial cells is a new and independent predictor of decreased DFS for patients with prostate cancer.
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DOI：
10.1083/jcb.143.5.1385
发表时间：
1998-11-30
期刊：
The Journal of cell biology
影响因子：
--
作者：
Sander EE;van Delft S;ten Klooster JP;Reid T;van der Kammen RA;Michiels F;Collard JG
通讯作者：
Collard JG
影响因子：
14.5
作者：
Price, LS;Collard, JG
通讯作者：
Collard, JG
影响因子：
5.6
作者：
Epstein, JI;Partin, AW;Walsh, PC
通讯作者：
Walsh, PC
影响因子：
64.8
作者：
Malliri, A;van der Kammen, RA;Collard, JG
通讯作者：
Collard, JG
影响因子：
64.8
作者：
QIU, RG;CHEN, J;SYMONS, M
通讯作者：
SYMONS, M