Eating the strangers within: host control of intracellular bacteria via xenophagy.
Eating the strangers within: host control of intracellular bacteria via xenophagy.
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DOI：
10.1111/j.1462-5822.2011.01632.x
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发表时间：
2011-09
影响因子：
3.4
通讯作者：
Celli J
中科院分区：
文献类型：
--
作者：
Knodler LA;Celli J
许多细菌病原体依靠细胞内周期来确保它们在被感染宿主内的增殖，通过它们避免或绕过宿主杀菌途径的能力。最近的证据支持自噬途径在对抗细胞内病原体的先天免疫防御中发挥越来越重要的作用，作为一种捕获细胞质适应性或空泡性细菌的机制，将它们重新定向到溶酶体室进行杀伤。抗菌自噬，也称为异种自噬，涉及细胞内细菌的选择性识别及其靶向自噬机制的降解。在这里，我们回顾了我们对这些过程的分子理解的最新进展，以及细菌如何适应避免异质吞噬甚至利用这种先天免疫过程。
Many bacterial pathogens rely on an intracellular cycle to ensure their proliferation within infected hosts, through their ability to avoid or circumvent host bactericidal pathways. Recent evidence supports an increasingly important role for the autophagy pathway in innate immune defenses against intracellular pathogens, as a mechanism of capture of either cytosol-adapted or vacuolar bacteria that redirect them to the lysosomal compartment for killing. Antibacterial autophagy, also referred to as xenophagy, involves selective recognition of intracellular bacteria and their targeting to the autophagic machinery for degradation. Here we review recent advances in our molecular understanding of these processes, and in how bacteria have adapted to avoid xenophagy or even take advantage of this innate immune process.
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影响因子：
7.5
作者：
Deretic V
通讯作者：
Deretic V
影响因子：
6.7
作者：
Collins CA;De Mazière A;van Dijk S;Carlsson F;Klumperman J;Brown EJ
通讯作者：
Brown EJ
影响因子：
13.3
作者：
Huang, Ju;Birmingham, Cheryl L.;Brumell, John H.
通讯作者：
Brumell, John H.
影响因子：
13.3
作者：
Cemma, Marija;Kim, Peter Kijun;Brumell, John Hunter
通讯作者：
Brumell, John Hunter
DOI：
10.1073/pnas.0601838103
发表时间：
2006-09-26
影响因子：
11.1
作者：
Checroun, Claire;Wehrly, Tara D.;Celli, Jean
通讯作者：
Celli, Jean