Alcohol Intake and Risk of Breast Cancer by Histologic Subtype and Estrogen Receptor Status Among Women Aged 55 to 74 Years.
Alcohol Intake and Risk of Breast Cancer by Histologic Subtype and Estrogen Receptor Status Among Women Aged 55 to 74 Years.
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在55至74岁的女性中，组织学亚型和雌激素受体状况的酒精摄入量和乳腺癌风险。
DOI：
10.1007/s12672-017-0297-2
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发表时间：
2017-08
影响因子：
3
通讯作者：
Li CI
中科院分区：
文献类型：
--
作者：
Baglia ML;Malone KE;Tang MC;Li CI
以前的研究表明，饮酒和乳腺癌风险可能会因组织学亚型和激素受体状态而有所不同，尽管结果并不完全一致。在这项基于人群的病例对照研究中，我们在55-74岁的女性中评估了饮酒与浸润性导管癌(IDC)、浸润性小叶癌(ILC)和浸润性导管小叶癌(IDLC)的总体风险以及雌激素受体(ER)状态之间的关系。使用多分类回归分析，在891名对照和905例IDC、567例ILC、489例IDLC患者中，评估了当前饮酒量、总体饮酒量和饮酒类型与乳腺癌风险的关系。目前饮酒与ILC的风险中等相关(优势比=1.2 5，95%可信区间：0.99，1.5 8)，基于每周平均饮酒次数的正剂量-反应关系(P趋势=0.0005)。当按ER状态进一步分层时，饮酒与ER+ILC(P趋势=0.002.0 1)和ER+IDC(P趋势=0.0 2)正相关，与ER−IDC风险负相关(P趋势=0.0 1)。未观察到酒精与IDLC肿瘤风险之间的关联。虽然饮酒和乳腺癌风险之间的联系已经确立，但我们的结果表明，与酒精相关的风险增加在很大程度上仅限于ER+ILC和ER+IDC。因此，避免或减少饮酒可能是女性降低患这些形式乳腺癌风险的一种方式。
Previous studies suggest that alcohol consumption and risk of breast cancer may differ by histologic subtype and hormone receptor status, though results are not entirely consistent. In this population-based case-control study, we evaluated the association between alcohol consumption and risk of invasive ductal carcinoma (IDC), invasive lobular carcinoma (ILC), and invasive ductal-lobular carcinoma (IDLC) overall and by estrogen receptor (ER) status, among women aged 55–74 years of age. Using polytomous regression, associations between current alcohol consumption, overall and by type of alcohol, and breast cancer risk were evaluated in 891 controls and 905 IDC, 567 ILC, 489 IDLC cases. Current alcohol use was moderately associated with risk of ILC (odds ratio=1.25, 95% confidence interval: 0.99, 1.58) with a positive dose-response relationship based on average number of drinks per week consumed (Ptrend=0.0005). When further stratified by ER status, alcohol use was positively associated with risk of ER+ ILC (Ptrend=0.002) and ER+ IDC (Ptrend=0.02), but inversely associated with risk of ER− IDC (Ptrend=0.01). No association between alcohol and risk of IDLC tumors was observed. While the link between alcohol consumption and breast cancer risk is well established, our results suggest that the increased risk associated with alcohol is largely limited to ER+ ILC and ER+ IDC. Thus, avoiding or moderating alcohol consumption may be one way that women can lower their risks of these forms of breast cancer.
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影响因子：
8.8
作者：
Beral, V;Hamajima, N;Hirose, K;Rohan, T;Calle, EE;Heath, CW;Coates, RJ;Liff, JM;Talamini, R;Chantarakul, N;Koetsawang, S;Rachawat, D;Morabia, A;Schuman, L;Stewart, W;Szklo, M;Bain, C;Schofield, F;Siskind, V;Band, P;Coldman, AJ;Gallagher, RP;Hislop, TG;Yang, P;Kolonel, LM;Nomura, AMY;Hu, J;Johnson, KC;Mao, Y;De Sanjose, S;Lee, N;Marchbanks, P;Ory, HW;Peterson, HB;Wilson, HG;Wingo, PA;Ebeling, K;Kunde, D;Nishan, P;Hopper, JL;Colditz, G;Gajalakshmi, V;Martin, N;Pardthaisong, T;Solpisornkosol, S;Theetranont, C;Boosiri, B;Chutivongse, S;Jimakorn, P;Virutamasen, P;Wongsrichanalai, C;Ewertz, M;Adami, HO;Bergkvist, L;Magnusson, C;Persson, I;Chang-Claude, J;Paul, C;Skegg, DCG;Spears, GFS;Boyle, P;Evstifeeva, T;Daling, JR;Hutchinson, WB;Malone, K;Noonan, EA;Stanford, JL;Thomas, DB;Weiss, NS;White, E;Andrieu, N;Brêmond, A;Clavel, F;Gairard, B;Lansac, J;Piana, L;Renaud, R;Izquierdo, A;Viladiu, P;Cuevas, HR;Ontiveros, P;Palet, A;Salazar, SB;Arsitizabal, N;Cuadros, A;Tryggvadottir, L;Tulinius, H;Bachelot, A;Lê, MG;Peto, J;Franceschi, S;Lubin, F;Modan, B;Ron, E;Wax, Y;Friedman, GD;Hiatt, RA;Levi, F;Bishop, T;Kosmelj, K;Primic-Zakelj, M;Ravnihar, B;Stare, J;Beeson, WL;Fraser, G;Bulbrook, RD;Cuzick, J;Duffy, SW;Fentiman, IS;Hayward, JL;Wang, DY;McMichael, AJ;McPherson, K;Hanson, RL;Leske, MC;Mahoney, MC;Nasca, PC;Varma, AO;Weinstein, AL;Moller, TR;Olsson, H;Ranstam, J;Goldbohm, RA;van den Brandt, PA;Apelo, RA;Baens, J;de la Cruz, JR;Javier, B;Lacaya, LB;Ngelangel, CA;La Vecchia, C;Negri, E;Marubini, E;Ferraroni, M;Gerber, M;Richardson, S;Segala, C;Gatei, D;Kenya, P;Kungu, A;Mati, JG;Brinton, LA;Hoover, R;Schairer, C;Spirtas, R;Lee, HP;Rookus, MA;van Leeuwen, FE;Schoenberg, JA;McCredie, M;Gammon, MD;Clarke, EA;Jones, L;Neil, A;Vessey, M;Yeates, D;Appleby, P;Banks, E;Bull, D;Crossley, B;Goodill, A;Green, J;Hermon, C;Key, T;Langston, N;Lewis, C;Reeves, G;Collins, R;Doll, R;Peto, R;Mabuchi, K;Preston, D;Hannaford, P;Kay, C;Rosero-Bixby, L;Gao, YT;Jin, F;Yuan, JM;Wei, HY;Yun, T;Zhiheng, C;Berry, G;Cooper Booth, J;Jelihovsky, T;MacLennan, R;Shearman, R;Wang, QS;Baines, CJ;Miller, AB;Wall, C;Lund, E;Stalsberg, H;Shu, XO;Zheng, W;Katsouyanni, K;Trichopoulou, A;Trichopoulos, D;Dabancens, A;Martinez, L;Molina, R;Salas, O;Alexander, XE;Anderson, K;Folsom, AR;Hulka, BS;Bernstein, L;Enger, S;Haile, RW;Paganini-Hill, A;Pike, MC;Ross, RK;Ursin, G;Yu, MC;Longnecker, MP;Newcomb, P;Bergkvist, L;Kalache, A;Farley, TMM;Holck, S;Meirik, O
通讯作者：
Meirik, O
影响因子：
3.8
作者：
Li, Christopher I.;Daling, Janet R.
通讯作者：
Daling, Janet R.
影响因子：
--
作者：
de Menezes, Raquel Ferreira;Bergmann, Anke;Santos Thuler, Luiz Claudio
通讯作者：
Santos Thuler, Luiz Claudio
影响因子：
5
作者：
Falk, Roni T.;Maas, Paige;Ziegler, Regina G.
通讯作者：
Ziegler, Regina G.
影响因子：
6.4
作者：
Suzuki, Reiko;Orsini, Nicola;Wolk, Alicja
通讯作者：
Wolk, Alicja