Neurocognitive impairment and patient-proxy agreement on health-related quality of life evaluations in recurrent high-grade glioma patients.
Neurocognitive impairment and patient-proxy agreement on health-related quality of life evaluations in recurrent high-grade glioma patients.
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DOI：
10.1007/s11136-022-03197-w
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发表时间：
2022-11
影响因子：
3.5
通讯作者：
Reijneveld, Jaap C.
中科院分区：
文献类型：
--
作者：
Caramanna, Ivan;Klein, Martin;van den Bent, Martin;Idbaih, Ahmed;Wick, Wolfgang;Taphoorn, Martin J. B.;Dirven, Linda;Bottomley, Andrew;Reijneveld, Jaap C.
随着时间的推移，脑肿瘤临床试验中患者报告的健康相关生活质量（HRQOL）数据的缺失率特别高。这个问题的一个解决方案是使用代理（即，伴侣、亲属、非正式护理者）评级代替患者报告结局（PRO）。在本研究中，我们调查了高级别胶质瘤（HGG）患者的HRQOL结果的患者代理协议。在参加EORTC试验26101和26091的501例患者-代理二元样本中，使用EORTC QLQ-C30和QLQ-BN 20评估了通用和疾病特异性HRQOL。根据患者的神经认知表现，将其分为受损或完好。使用Lin的一致性相关系数（CCC）和Bland-Altman一致性限测量患者-代理协议的水平。使用Wilcoxon符号秩检验评估患者和代理人的HRQOL之间的差异。所有HGG患者（N = 501）的患者-代理一致率范围为0.082 - 0.460。只有18.8%的患者神经认知功能完好。认知功能受损患者及其代理人的林氏CCC范围为0.088至0.455，认知功能完好患者及其代理人的范围为0.027至0.538。虽然患者代理协议的健康相关的生活质量的结果是认知功能完好的患者略高，在高级别胶质瘤患者的协议一般是低的。根据这些发现，我们建议谨慎考虑使用代理评估代替患者报告的结果，无论患者的神经认知状态如何。在线版本包含补充材料，可通过10.1007/s11136-022-03197-w获取。
The rate of missing data on patient-reported health-related quality of life (HRQOL) in brain tumor clinical trials is particularly high over time. One solution to this issue is the use of proxy (i.e., partner, relative, informal caregiver) ratings in lieu of patient-reported outcomes (PROs). In this study we investigated patient–proxy agreement on HRQOL outcomes in high-grade glioma (HGG) patients. Generic and disease-specific HRQOL were assessed using the EORTC QLQ-C30 and QLQ-BN20 in a sample of 501 patient–proxy dyads participating in EORTC trials 26101 and 26091. Patients were classified as impaired or intact, based on their neurocognitive performance. The level of patient–proxy agreement was measured using Lin’s concordance correlation coefficient (CCC) and the Bland–Altman limit of agreement. The Wilcoxon signed-rank test was used to evaluate differences between patients’ and proxies’ HRQOL. Patient–proxy agreement in all HGG patients (N = 501) ranged from 0.082 to 0.460. Only 18.8% of all patients were neurocognitively intact. Lin’s CCC ranged from 0.088 to 0.455 in cognitively impaired patients and their proxies and from 0.027 to 0.538 in cognitively intact patients and their proxies. While patient–proxy agreement on health-related quality of life outcomes is somewhat higher in cognitively intact patients, agreement in high-grade glioma patients is low in general. In light of these findings, we suggest to cautiously consider the use of proxy’s evaluation in lieu of patient-reported outcomes, regardless of patient’s neurocognitive status. The online version contains supplementary material available at 10.1007/s11136-022-03197-w.
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影响因子：
6.2
作者：
Wefel, Jeffrey S.;Saleeba, Angele K.;Meyers, Christina A.
通讯作者：
Meyers, Christina A.
DOI：
10.1093/jee/39.2.269
发表时间：
1945-01-01
期刊：
BIOMETRICS BULLETIN
影响因子：
--
作者：
WILCOXON, F
通讯作者：
WILCOXON, F
影响因子：
2.6
作者：
Tombaugh, TN
通讯作者：
Tombaugh, TN
影响因子：
3.5
作者：
Ediebah, Divine E.;Reijneveld, Jaap C.;Klein, Martin
通讯作者：
Klein, Martin
影响因子：
3.9
作者：
Benedict, RHB;Schretlen, D;Brandt, J
通讯作者：
Brandt, J