Exploiting Flow Dynamics for Superresolution in Contrast-Enhanced Ultrasound
Exploiting Flow Dynamics for Superresolution in Contrast-Enhanced Ultrasound
复制标题
利用流动动力学实现超声造影中的超分辨率
DOI：
10.1109/tuffc.2019.2926062
复制
发表时间：
2018
期刊：
影响因子：
--
通讯作者：
Yonina C. Eldar
中科院分区：
文献类型：
--
作者：
Oren Solomon;R. V. van Sloun;H. Wijkstra;M. Mischi;Yonina C. Eldar
超声（US）定位显微镜为组织深处的血管成像提供了新的无辐射诊断工具。从血流内具有低浓度的惰性微泡（MB）返回的回波的顺序定位揭示了具有毛细血管分辨率的脉管系统。尽管其空间分辨率高，但低MB浓度要求在几秒到几十秒的过程中获取数万张图像，以产生单个超分辨率图像。这种长的采集时间和对MB浓度的严格限制在许多临床情况下是不期望的。为了解决这些限制，最近开发了基于稀疏性的方法。这些方法显著减少了总采集时间，同时在具有相当大MB重叠的设置中保持良好的空间分辨率。在这里，我们进一步提高了空间分辨率和视觉血管重建质量的稀疏为基础的超分辨率超声成像从低帧速率采集，通过利用固有的流动MB和利用他们的运动运动学。我们还提供了MB速度的定量测量，并表明我们的方法实现了更高的MB召回率比国家的最先进的技术，同时增加造影剂浓度。我们的方法依赖于以逐帧的方式对各个MB进行同时跟踪和基于稀疏性的检测，因此，可以适合于实时实现。所提出的方法的有效性证明了在两个模拟和在体内对比度增强的人前列腺扫描，获得临床批准的扫描仪在10 Hz的帧速率。
Ultrasound (US) localization microscopy offers new radiation-free diagnostic tools for vascular imaging deep within the tissue. Sequential localization of echoes returned from inert microbubbles (MBs) with low concentration within the bloodstream reveals the vasculature with capillary resolution. Despite its high spatial resolution, low MB concentrations dictate the acquisition of tens of thousands of images, over the course of several seconds to tens of seconds, to produce a single superresolved image. Such long acquisition times and stringent constraints on MB concentration are undesirable in many clinical scenarios. To address these restrictions, sparsity-based approaches have recently been developed. These methods reduce the total acquisition time dramatically, while maintaining good spatial resolution in settings with considerable MB overlap. Here, we further improve the spatial resolution and visual vascular reconstruction quality of sparsity-based superresolution US imaging from low-frame rate acquisitions, by exploiting the inherent flow of MBs and utilize their motion kinematics. We also provide quantitative measurements of MB velocities and show that our approach achieves higher MB recall rate than the state-of-the-art techniques, while increasing contrast agents concentration. Our method relies on simultaneous tracking and sparsity-based detection of individual MBs in a frame-by-frame manner, and as such, may be suitable for real-time implementation. The effectiveness of the proposed approach is demonstrated on both simulations and an in vivo contrast-enhanced human prostate scan, acquired with a clinically approved scanner operating at a 10-Hz frame rate.
影响因子：
3.8
作者：
O'Reilly, Meaghan A.;Hynynen, Kullervo
通讯作者：
Hynynen, Kullervo
登记。
DOI：
10.1007/978-1-4939-7647-8_1
发表时间：
2018
期刊：
Neuromethods
影响因子：
--
作者：
Joshi,AnandA
通讯作者：
Joshi,AnandA