The possible association between epidemics of hand-foot-and-mouth disease and responsiveness to immunoglobulin therapy in Kawasaki disease.
The possible association between epidemics of hand-foot-and-mouth disease and responsiveness to immunoglobulin therapy in Kawasaki disease.
复制标题
川崎疾病中的手脚疾病流行与免疫球蛋白治疗的反应之间的可能关联。
DOI：
10.3389/fped.2022.968857
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发表时间：
2022
影响因子：
2.6
通讯作者：
Kusuhara, Koichi
中科院分区：
文献类型：
--
作者：
Shimizu, Daisuke;Hoshina, Takayuki;Kawamura, Masaru;Tomita, Yoshie;Hidaka, Yasufumi;Kojiro, Masumi;Muneuchi, Jun;Kamizono, Junji;Yamaguchi, Kenichiro;Fujino, Yoshihisa;Kusuhara, Koichi
关键词：
肠道病毒引起的手足口病（HFMD）已被报道与川崎病（KD）的发展有关，而肠道病毒在KD的临床过程中的参与尚不确定。本研究的目的是探讨KD临床病程与手足口病流行之间的关系。这项研究包括108名在2010年至2014年手足口病流行季节（7月和8月）期间发生KD的患者，他们最初接受了大剂量静脉注射免疫球蛋白（IVIG）治疗。每个哨点医疗机构平均每周报告≥5.0例手足口病患者被认为代表了大规模的手足口病流行。我们比较了有和没有大规模手足口病流行年份夏季KD患者的临床特征。2011年和2013年发生了大规模手足口病疫情。2011年夏季患儿数最多。IVIG治疗抵抗的患者比例（14%）在夏季大流行的年份（31%，P = 0.030）显着低于其他年份的夏季，而冠状动脉异常的患者比例没有统计学差异。大规模手足口病流行期间KD的发生与IVIG治疗耐药风险降低显著相关（发病率比0.92，P = 0.049）。在大规模手足口病流行期间发生KD的患者可能对IVIG有良好的反应性。从KD患者中鉴定微生物对预测IVIG治疗的反应性是重要的。
Enterovirus causing hand-foot-mouth disease (HFMD) has been reported to be associated with the development of Kawasaki disease (KD), whereas the involvement of enterovirus in the clinical course of KD is uncertain. The aim of this study is to investigate the association between the clinical course of KD and HFMD epidemics. This study included 108 patients who developed KD during HFMD epidemic seasons (July and August) from 2010 to 2014 and who were initially treated with high-dose intravenous immunoglobulin (IVIG). A mean of ≥5.0 HFMD patients reported weekly from each sentinel medical facility was considered to represent a large HFMD epidemic. We compared the clinical characteristics of KD patients in summers of years with and without large HFMD epidemics. Large HFMD epidemics occurred in 2011 and 2013. The number of KD patients in summer was the highest in 2011. The proportion of patients with resistance to the IVIG therapy in summers of years with the large epidemics (14%) was significantly lower than that in summers of other years (31%, P = 0.030), whereas the proportion of patients with coronary artery abnormalities did not differ to a statistically significant extent. The development of KD during large HFMD epidemics was significantly associated with a lower risk of resistance to the IVIG therapy (incidence rate ratio 0.92, P = 0.049). Patients developing KD during large HFMD epidemic may have good responsiveness to IVIG. It is important to identify microbes from KD patients to predict responsiveness to IVIG therapy.
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影响因子：
37.8
作者：
Kobayashi, Tohru;Inoue, Yoshinari;Morikawa, Akihiro
通讯作者：
Morikawa, Akihiro
影响因子：
2.6
作者：
Tsai CM;Yu HR;Tang KS;Huang YH;Kuo HC
通讯作者：
Kuo HC
影响因子：
2.9
作者：
Kim GB;Park S;Kwon BS;Han JW;Park YW;Hong YM
通讯作者：
Hong YM
影响因子：
11.8
作者：
ABZUG, MJ;KEYSERLING, HL;ROTBART, HA
通讯作者：
ROTBART, HA
通过商业静脉免疫球蛋白产品从2014年美国暴发中分离出的肠病毒D68中和肠病毒病毒D68。
DOI：
10.1016/j.jcv.2015.06.086
发表时间：
2015-08
期刊：
Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology
影响因子：
--
作者：
Zhang Y;Moore DD;Nix WA;Oberste MS;Weldon WC
通讯作者：
Weldon WC