The centrosome - diverse functions in fertilization and development across species.
The centrosome - diverse functions in fertilization and development across species.
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DOI：
10.1242/jcs.261387
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发表时间：
2023-12-01
影响因子：
4
通讯作者：
中科院分区：
文献类型：
--
作者：
中心体是一种非膜结合的细胞器，在大多数动物细胞中是保守的，并在整个细胞周期中发挥各种功能。在分裂的细胞中，中心体被称为纺锤体极，并使一个坚固的微管纺锤体成为核，将遗传物质均等地分成两个子细胞。在不分裂的细胞中，中心体的亚结构--中心粒母细胞成熟为基体，并使纤毛成核，纤毛起着信号传导天线的作用。中心体及其亚结构的功能对于胚胎发育是重要的，并且已经使用体外哺乳动物细胞培养或使用无脊椎动物模型在体内进行了广泛的研究。然而，在脊椎动物发育的不同阶段，中心体的组成和功能存在很大的差异，这些研究较少。在这篇综述中，我们讨论了中心体所发挥的作用，强调了物种之间的保守和不同的功能，特别是在受精和胚胎发育过程中。总结：深入研究中心体，这篇综述讨论了它们在动物细胞中的多功能作用，强调了它们在不同物种的受精和胚胎发育过程中的不同功能。
The centrosome is a non-membrane-bound organelle that is conserved across most animal cells and serves various functions throughout the cell cycle. In dividing cells, the centrosome is known as the spindle pole and nucleates a robust microtubule spindle to separate genetic material equally into two daughter cells. In non-dividing cells, the mother centriole, a substructure of the centrosome, matures into a basal body and nucleates cilia, which acts as a signal-transducing antenna. The functions of centrosomes and their substructures are important for embryonic development and have been studied extensively using in vitro mammalian cell culture or in vivo using invertebrate models. However, there are considerable differences in the composition and functions of centrosomes during different aspects of vertebrate development, and these are less studied. In this Review, we discuss the roles played by centrosomes, highlighting conserved and divergent features across species, particularly during fertilization and embryonic development. Summary: Delving into centrosomes, this Review discusses their versatile roles in animal cells, emphasizing their diverse functions during fertilization and embryonic development across species.
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影响因子：
13.6
作者：
Kalbfuss, Nils;Gonczy, Pierre
通讯作者：
Gonczy, Pierre
影响因子：
2.6
作者：
Albertson, Donna G.;Thomson, J. Nichol
通讯作者：
Thomson, J. Nichol
影响因子：
4.5
作者：
通讯作者：
--
DOI：
10.1242/dev.198762
发表时间：
2022-08-15
期刊：
Development (Cambridge, England)
影响因子：
--
作者：
通讯作者：
--
影响因子：
9.2
作者：
Conduit, Paul T.;Brunk, Kathrin;Raff, Jordan W.
通讯作者：
Raff, Jordan W.