Induction of differentiation of human and mouse myeloid leukemia cells by camptothecin.
Induction of differentiation of human and mouse myeloid leukemia cells by camptothecin.
复制标题
喜树碱诱导人和小鼠骨髓白血病细胞的分化。
DOI：
10.1016/0006-291x(90)91925-i
复制
发表时间：
1990
影响因子：
3.1
通讯作者：
Y. Nakamura
中科院分区：
文献类型：
--
作者：
S. Chou;M. Kaneko;K. Nakaya;Y. Nakamura
低浓度的喜树碱诱导分化的人类和小鼠髓性白血病细胞，包括人类HL 60，U937，ML 1，和K562细胞和小鼠M1细胞，通过各种分化相关的性能进行测量。当用20 nM喜树碱预处理K562细胞2 h时，通过NBT染色测量，53%的细胞被诱导分化。该处理导致K562细胞DNA的显著单链断裂。大多数单链断裂伴随着蛋白质-DNA交联。喜树碱和rTNF的组合协同诱导人ML 1、U937和ML细胞的分化。这些结果表明，拓扑异构酶I可能是重要的一些髓系白血病细胞的分化。
Low concentrations of camptothecin induced differentiation of human and mouse myeloid leukemia cells including human HL60, U937, ML1, and K562 cells and mouse M1 cells as measured by various differentiation-associated properties. When K562 cells were pretreated with 20 nM camptothecin for 2 h, 53% of the cells were induced to differentiate as measured by NBT staining. Significant single strand breaks in DNA of K562 cells were caused by this treatment. Most single strand breaks were accompanied by protein-DNA cross linking. The combination of camptothecin and rTNF synergistically induced differentiation of human ML1, U937, and ML cells. These results suggest that topo I may be important in some differentiation of myeloid leukemia cells.
新生霉素和佛波醇 12-肉豆蔻酸酯-13-乙酸酯诱导的人类白血病细胞分化与拓扑异构酶 II 活性降低相关。
影响因子：
11.2
作者：
Constantinou,A;Henning-Chubb,C;Huberman,E
通讯作者：
Huberman,E
γ 干扰素诱导 HL-60 细胞系中的单核细胞分化。
DOI：
10.1172/jci111292
发表时间：
1984
期刊：
The Journal of clinical investigation
影响因子：
--
作者：
Ball,ED;Guyre,PM;Shen,L;Glynn,JM;Maliszewski,CR;Baker,PE;Fanger,MW
通讯作者：
Fanger,MW