Adiposity is associated with blunted cardiovascular, neuroendocrine and cognitive responses to acute mental stress.
Adiposity is associated with blunted cardiovascular, neuroendocrine and cognitive responses to acute mental stress.
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DOI：
10.1371/journal.pone.0039143
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发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
Muthurangu V
中科院分区：
文献类型：
--
作者：
Jones A;McMillan MR;Jones RW;Kowalik GT;Steeden JA;Deanfield JE;Pruessner JC;Taylor AM;Muthurangu V
肥胖和精神压力是心血管疾病的潜在危险因素，但它们之间的关系尚不清楚。根据肥胖程度的不同，对压力的适应能力可能不同。由于相互矛盾的发现和有限的方法，解决这一问题的早期研究很难解释。在评估心血管应激反应和脂肪分布方面的最新进展使准确评估肥胖和应激反应之间的关系成为可能。我们测量了健康男性(N = 43)和女性(N = 45)对蒙特利尔成像应激任务的反应，这些人的BMI范围很大。心率(HR)和血压(BP)测量与新的磁共振测量(每搏量(SV)、心输出量(CO)、总外周阻力(TPR)和动脉顺应性)一起用于评估心血管反应。唾液皮质醇和数学问题答案的数量和速度分别被用来评估神经内分泌和认知反应。使用T2*-Ideas测量内脏和皮下脂肪。较大的体重指数与心血管的全面性钝化有关(HR：β = −0.50bpm.单位−1，P = 0.009；SV：β = −0.33mL.单位−1，P = 0.01；CO：β = −61mL.min−1.单位−1，P = 0.002；收缩压：β = −0.41mmHg.单位−1，P = 0.01；TPR：β = 0.11WU，单位−1，P = 0.02)，认知(正确答案：R = −0.28，P = 0.01；回答时间：R = 0.26，P = 0.02)和内分泌反应(皮质醇：R = −0.25，P = 0.04)。这些关联很大程度上是由内脏肥胖决定的，除了与认知能力有关的那些，这是由内脏和皮下脂肪决定的。我们的发现表明，肥胖与中枢的应激反应能力降低有关。虽然这可能会缓解压力反应的一些长期健康风险，但在压力下表现下降可能是一个更直接的负面后果。
Obesity and mental stress are potent risk factors for cardiovascular disease but their relationship with each other is unclear. Resilience to stress may differ according to adiposity. Early studies that addressed this are difficult to interpret due to conflicting findings and limited methods. Recent advances in assessment of cardiovascular stress responses and of fat distribution allow accurate assessment of associations between adiposity and stress responsiveness. We measured responses to the Montreal Imaging Stress Task in healthy men (N = 43) and women (N = 45) with a wide range of BMIs. Heart rate (HR) and blood pressure (BP) measures were used with novel magnetic resonance measures of stroke volume (SV), cardiac output (CO), total peripheral resistance (TPR) and arterial compliance to assess cardiovascular responses. Salivary cortisol and the number and speed of answers to mathematics problems in the task were used to assess neuroendocrine and cognitive responses, respectively. Visceral and subcutaneous fat was measured using T2 *-IDEAL. Greater BMI was associated with generalised blunting of cardiovascular (HR:β = −0.50 bpm.unit−1, P = 0.009; SV:β = −0.33 mL.unit−1, P = 0.01; CO:β = −61 mL.min−1.unit−1, P = 0.002; systolic BP:β = −0.41 mmHg.unit−1, P = 0.01; TPR:β = 0.11 WU.unit−1, P = 0.02), cognitive (correct answers: r = −0.28, P = 0.01; time to answer: r = 0.26, P = 0.02) and endocrine responses (cortisol: r = −0.25, P = 0.04) to stress. These associations were largely determined by visceral adiposity except for those related to cognitive performance, which were determined by both visceral and subcutaneous adiposity. Our findings suggest that adiposity is associated with centrally reduced stress responsiveness. Although this may mitigate some long-term health risks of stress responsiveness, reduced performance under stress may be a more immediate negative consequence.
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