Correlates of Adiponectin and the Leptin/Adiponectin Ratio in Obese and Non-obese Children
Correlates of Adiponectin and the Leptin/Adiponectin Ratio in Obese and Non-obese Children
复制标题
肥胖和非肥胖儿童脂联素与瘦素/脂联素比率的相关性
DOI：
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发表时间：
2004
期刊：
影响因子：
--
通讯作者：
D. Eichler
中科院分区：
文献类型：
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作者：
F. Diamond;D. Cuthbertson;Suzan Hanna;D. Eichler
脂联素是一种脂肪细胞分泌的蛋白质，已被报道可增加脂肪酸氧化和改善胰岛素敏感性。我们的目的是研究肥胖儿童脂联素与瘦素、体脂、胰岛素和脂蛋白的关系，并与年龄和性别匹配的非肥胖儿童进行比较。肥胖组儿童血清脂联素水平显著低于非肥胖组(9.1±-3.7vs17.1+/-12.3microg/ml，p<；0.001)，而肥胖组血清瘦素水平高于非肥胖组(31.8vs8.2+/-5.7ng/ml，p<；0.05)。当被认为是评估不同体型范围内脂联素浓度的单一组时，脂联素的值与体重(r=-0.33，p<；0.05)和体重指数(r=-0.35，p<；0.05)呈负相关。脂联素与高密度脂蛋白胆固醇直接相关(r=0.47p<；0.005)，但与总胆固醇、胰岛素样生长因子-I或瘦素结合活性无关。由于瘦素和脂联素与体重指数呈负相关，瘦素/脂联素(L/A)比值被确定为肥胖与肥胖并发症发生有关的潜在指标。肥胖组的L/A比值是非肥胖组的8倍，并且与体重指数(r=0.779，p<；0.0001)和高密度脂蛋白胆固醇(r=-0.53，p<；0.001)的相关性比单独使用脂联素更强。在非肥胖儿童中，L/A比值与三头肌皮褶厚度(r=0.77p<；0.001)和体脂百分比(r=0.79p<；0.0001)也呈显著正相关。这些数据表明，脂联素浓度在儿童肥胖症中已经得到了不同的调节。经脂联素降低校正的瘦素浓度升高指数(L/A比率)值得研究，作为儿童肥胖相关疾病的标志。
Adiponectin is an adipocyte secreted protein that has been reported to increase fatty acid oxidation and improve insulin sensitivity. Our aim was to study the relationship between adiponectin and leptin, body fat, insulin and lipoproteins in obese compared to non-obese children matched for age and gender. Adiponectin serum concentrations were significantly lower in the obese compared to the non-obese children (9.1+/-3.7 vs 17.1+/-12.3 microg/ml, p <0.05), in contrast to serum leptin concentrations which were greater in the obese compared to the non-obese subjects (31.8+/-11.1 vs 8.2+/-5.7 ng/ml, p <0.001). When considered as a single group to assess adiponectin concentrations over a spectrum of body size, adiponectin values correlated inversely with body weight (r = -0.33, p <0.05) and BMI (r = -0.35, p <0.05). Adiponectin values correlated directly with HDL-C (r = 0.47, p <0.005), but not with total cholesterol, IGF-I, or leptin binding activity. Since leptin and adiponectin change inversely in relation to BMI, the leptin/adiponectin (L/A) ratio was determined as a potential index relating adiposity to the development of complications of obesity. The L/A ratio was eight-fold greater in the obese compared to the non-obese children, and correlated more strongly with BMI (r = 0.779, p <0.0001) and with HDL-C (r = -0.53, p <0.001), than did adiponectin alone. The L/A ratio also correlated significantly with triceps skinfold thickness (TSF) (r = 0.77, p <0.001) and percent body fat (r = 0.79, p <0.0001) in non-obese children. These data suggest that adiponectin concentrations are already differentially regulated in childhood obesity. The index of increased leptin concentration corrected by reduced adiponectin values (L/A ratio) merits investigation as a marker for morbidities associated with childhood obesity.
影响因子：
16.2
作者：
Lindsay, RS;Walker, JD;Johnstone, FD
通讯作者：
Johnstone, FD
DOI：
10.1210/jcem.82.4.3878
发表时间：
1997-04
期刊：
The Journal of clinical endocrinology and metabolism
影响因子：
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作者：
C. Mantzoros;J. Flier;A. Rogol
通讯作者：
C. Mantzoros;J. Flier;A. Rogol