Cognate Ligand Chaperoning: a Novel Mechanism for the Post-translational Regulation of Neurotransmitter Receptor Biogenesis.
Cognate Ligand Chaperoning: a Novel Mechanism for the Post-translational Regulation of Neurotransmitter Receptor Biogenesis.
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DOI：
10.3389/fncel.2017.00245
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发表时间：
2017
影响因子：
5.3
通讯作者：
Leidenheimer NJ
中科院分区：
文献类型：
--
作者：
Leidenheimer NJ
中枢神经系统中神经元间通讯的功能单位是神经元突触。细胞表面突触后神经递质受体的数量是突触功效和可塑性的重要决定因素。多种翻译后过程调节突触后受体数量，包括受体胞吐、侧向扩散、表面稳定、内吞和再循环，从而突出了控制突触后受体水平的机制的重要性。另一个公认的调节受体表面表达的翻译后机制是同源配体伴侣作用。已经提出神经递质作为同源配体伴侣通过在内质网（ER）腔内结合到它们的新生神经递质受体并促进受体生物发生而起作用。在这里，我们讨论了概念验证的证据，小分子可以选择性地促进其目标的生物合成，并检查支持神经递质受体生物合成的同源配体伴侣的具体证据。
The functional unit for inter-neuronal communication in the central nervous system is the neuronal synapse. The number of postsynaptic neurotransmitter receptors at the cell surface is an important determinant of synaptic efficacy and plasticity. A diverse array of post-translational processes regulate postsynaptic receptor number, including receptor exocytosis, lateral diffusion, surface stabilization, endocytosis, and recycling, thus highlighting the importance of mechanisms that control postsynaptic receptor levels. Another putative post-translational mechanism for regulating receptor surface expression is cognate ligand chaperoning. It has been proposed that neurotransmitters function as cognate ligand chaperones by binding, within the endoplasmic reticulum (ER) lumen, to their nascent neurotransmitter receptors and facilitating receptor biogenesis. Here we discuss proof-of-concept evidence that small molecules can selectively facilitate the biogenesis of their targets and examine the specific evidence in support of cognate ligand chaperoning of neurotransmitter receptor biogenesis.
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影响因子：
--
作者：
Corringer, PJ;Sallette, J;Changeux, JP
通讯作者：
Changeux, JP
影响因子：
16.2
作者：
Cajigas IJ;Tushev G;Will TJ;tom Dieck S;Fuerst N;Schuman EM
通讯作者：
Schuman EM
DOI：
10.1523/jneurosci.3340-09.2009
发表时间：
2009-10-14
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Belelli D;Harrison NL;Maguire J;Macdonald RL;Walker MC;Cope DW
通讯作者：
Cope DW
影响因子：
11.4
作者：
Christianson, JC;Green, WN
通讯作者：
Green, WN
影响因子：
2.6
作者：
Cao, Juxiang;Barbosa, Jose M.;Locy, Robert D.
通讯作者：
Locy, Robert D.