The role of CO(2) and central chemoreception in the control of breathing in the fetus and the neonate.
The role of CO(2) and central chemoreception in the control of breathing in the fetus and the neonate.
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DOI：
10.1016/j.resp.2010.04.009
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发表时间：
2010-10-31
影响因子：
2.3
通讯作者：
Darnall, Robert A.
中科院分区：
文献类型：
--
作者：
Darnall, Robert A.
中枢化学感受在发育早期活跃，可能驱动胎儿呼吸运动，而胎儿呼吸运动受到行为状态和强大抑制的综合影响。在早产人类婴儿和新生大鼠中，通气量因二氧化碳的反应而增加；在大鼠中，反应的敏感性在~P12之后稳定增加。早产儿比新生大鼠更容易不稳定，并表现出周期性呼吸，缺氧会加剧这种呼吸，呼吸氧气或二氧化碳或施用呼吸兴奋剂会消除这种呼吸。胎儿中枢化学感受活跃的部位尚不清楚，但可能涉及面旁呼吸群，这可能是成人 RTN 的前身。胎儿和新生大鼠脑干脊髓制剂有望提供有关发育中的啮齿动物中枢化学感受的重要信息，并将增加我们对重要临床问题的理解，包括婴儿猝死综合征、先天性中枢性通气不足综合征以及早产儿周期性呼吸和呼吸暂停。
Central chemoreception is active early in development and likely drives fetal breathing movements, which are influenced by a combination of behavioral state and powerful inhibition. In the premature human infant and newborn rat ventilation increases in response to CO2; in the rat the sensitivity of the response increases steadily after ~P12. The premature human infant is more vulnerable to instability than the newborn rat and exhibits periodic breathing that is augmented by hypoxia and eliminated by breathing oxygen or CO2 or the administration of respiratory stimulants. The sites of central chemoreception active in the fetus are not known, but may involve the parafacial respiratory group which may be a precursor to the adult RTN. The fetal and neonatal rat brainstem spinal-cord preparations promise to provide important information about central chemoreception in the developing rodent and will increase our understanding of important clinical problems, including The Sudden Infant Death Syndrome, Congenital Central Hypoventilation Syndrome, and periodic breathing and apnea of prematurity.
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影响因子：
2.3
作者：
Corcoran, Andrea E.;Hodges, Matthew R.;Wu, Yuanming;Wang, Wengang;Wylie, Christie J.;Deneris, Evan S.;Richerson, George B.
通讯作者：
Richerson, George B.
影响因子：
3.3
作者：
ADAMSON, SL;KUIPERS, IM;OLSON, DM
通讯作者：
OLSON, DM
影响因子：
3.6
作者：
Cardot, Virginie;Chardon, Karen;Telliez, Frederic
通讯作者：
Telliez, Frederic
DOI：
10.1016/s0034-5687(01)00303-6
发表时间：
2001-11-01
期刊：
RESPIRATION PHYSIOLOGY
影响因子：
--
作者：
Dauger, S;Aizenfisz, S;Gallego, J
通讯作者：
Gallego, J
DOI：
10.1152/ajpregu.91011.2008
发表时间：
2009-07-01
影响因子：
2.8
作者：
Cummings, Kevin J.;Frappell, Peter B.
通讯作者：
Frappell, Peter B.