High relaxivity trimetallic nitride (Gd3N) metallofullerene MRI contrast agents with optimized functionality.
High relaxivity trimetallic nitride (Gd3N) metallofullerene MRI contrast agents with optimized functionality.
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DOI：
10.1021/bc900375n
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发表时间：
2010-04-21
影响因子：
4.7
通讯作者：
Dorn, Harry C.
中科院分区：
文献类型：
--
作者：
Zhang, Jianfei;Fatouros, Panos P.;Shu, Chunying;Reid, Jonathan;Owens, Lesley Shantell;Cai, Ting;Gibson, Harry W.;Long, Gary L.;Corwin, Frank D.;Chen, Zhi-Jian;Dorn, Harry C.
合成了水溶性聚乙二醇（PEG）功能化和羟基化的内嵌三金属氮化金属富勒烯衍生物Gd3N@C80[DiPEG(OH)x]，并对其进行了表征。在0.35 T、2.4 T和9.4 T下测量了四种不同分子量PEG衍生物（350-5000 Da）在水溶液中的1H MRI弛豫值，发现350/750 Da PEG衍生物的弛豫值最高，r1为237/232 mM−1s−1，r2为460/398 mM−1s−1（基于Gd3+离子分别为79/77 mM−1s−1和153/133 mM−1s−1）。在2.4 t的临床范围磁场下，这些代表了文献中报道的任何商业或研究性MRI造影剂的最高弛豫度。动态光散射结果证实了350/750 Da PEG衍生物（95/96 nm）相对于长链衍生物，5000 Da PEG衍生物（37nm）的尺寸分布更大。将优化的350 Da PEG衍生物直接输注到活的肿瘤大鼠大脑中，显示出初始均匀分布，因此，当包封的Gd3+离子被放射性的177Lu取代时，具有有效的近距离治疗应用的潜力。
The water soluble poly(ethylene glycol) (PEG) functionalized and hydroxylated endohedral trimetallic nitride metallofullerene derivatives, Gd3N@C80[DiPEG(OH)x], have been synthesized and characterized. The 1H MRI relaxivities in aqueous solution were measured for the derivatives with four different molecular weights of PEG (350–5000 Da) at 0.35 T, 2.4 T and 9.4 T. The 350/750 Da PEGs derivatives were found to have the highest relaxivities values among the derivatives, 237/232 mM−1s−1 for r1 and 460/398 mM−1s−1 for r2 (79/77 mM−1s−1 and 153/133 mM−1s−1 based on Gd3+ ion) respectively, at a clinical-range magnetic field of 2.4 T. These represent some of the highest relaxivities reported in the literatures for any commercial or investigational MRI contrast agent. Dynamic light scattering results confirm a larger size distribution for 350/750 Da PEGs derivatives (95/96 nm) relative to longer chain length derivatives, 5000 Da PEG derivatives (37nm). Direct infusion of the optimized 350 Da PEG derivatives into live tumor-bearing rat brains demonstrated an initial uniform distribution and hence, the potential for effective brachytherapy applications when the encapsulated Gd3+ ions are replaced with radioactive 177Lu.
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影响因子：
8.6
作者：
Shu, Chun-Ying;Wang, Chun-Ru;Dennis, T. John S.
通讯作者：
Dennis, T. John S.
影响因子：
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Dorn, HC
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影响因子：
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作者：
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通讯作者：
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