Emerging role of ISG15 in antiviral immunity.

Emerging role of ISG15 in antiviral immunity.
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DOI:
10.1016/j.cell.2010.09.033
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发表时间:
2010-10-15
期刊:
影响因子:
64.5
通讯作者:
Chen ZJ
Chen ZJ
中科院分区:
生物学1区
文献类型:
--
作者:
Skaug B;Chen ZJ

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细胞表达大量干扰素刺激基因(ISG)以响应病毒感染。其中之一是ISG15,一种泛素样蛋白(UBL),可以共价连接到宿主和病毒蛋白。本文综述了ISG15修饰在抗病毒防御中的作用和机制。
Cells express a plethora of interferon-stimulated genes (ISGs) in response to viral infection. Among these is ISG15, a ubiquitin-like protein (UBL), that can be covalently attached to both host and viral proteins. Here we review recent advances towards understanding the role and mechanism of ISG15 modification in antiviral defense.
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