Transcription factors involved in retinogenesis are co-opted by the circadian clock following photoreceptor differentiation.
Transcription factors involved in retinogenesis are co-opted by the circadian clock following photoreceptor differentiation.
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DOI：
10.1242/dev.104380
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发表时间：
2014-07
期刊：
影响因子：
--
通讯作者：
Whitmore D
中科院分区：
文献类型：
--
作者：
Laranjeiro R;Whitmore D
已知生物钟调节广泛的生理和细胞过程，但对其在胚胎发育过程中的作用知之甚少。斑马鱼为探索这一问题提供了一个独特的机会，这不仅是因为我们对这一物种的关键发育事件有很多了解，而且还因为生物钟从发育的第一天开始。在这项研究中，我们确定了许多节奏基因在斑马鱼幼虫，包括关键的转录调控neurod和cdx1b，这是参与神经元和肠道分化，分别。只有在发育中的视网膜中才观察到neurod和几个额外的转录因子的节律性表达。令人惊讶的是，这些节奏的表达开始在一个阶段的发展后，这些转录因子被称为发挥其重要作用，在感光细胞分化。此外，这种昼夜节律调节在成年视网膜中得以维持。因此，一旦形成成熟的光感受器，多种视网膜转录因子就受到昼夜节律钟的控制，此时它们似乎在调节光转导途径中的节律元件中发挥新的重要作用。
The circadian clock is known to regulate a wide range of physiological and cellular processes, yet remarkably little is known about its role during embryo development. Zebrafish offer a unique opportunity to explore this issue, not only because a great deal is known about key developmental events in this species, but also because the clock starts on the very first day of development. In this study, we identified numerous rhythmic genes in zebrafish larvae, including the key transcriptional regulators neurod and cdx1b, which are involved in neuronal and intestinal differentiation, respectively. Rhythmic expression of neurod and several additional transcription factors was only observed in the developing retina. Surprisingly, these rhythms in expression commenced at a stage of development after these transcription factors are known to have played their essential role in photoreceptor differentiation. Furthermore, this circadian regulation was maintained in adult retina. Thus, once mature photoreceptors are formed, multiple retinal transcription factors fall under circadian clock control, at which point they appear to play a new and important role in regulating rhythmic elements in the phototransduction pathway.
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