Graded Control of Climbing-Fiber-Mediated Plasticity and Learning by Inhibition in the Cerebellum.
Graded Control of Climbing-Fiber-Mediated Plasticity and Learning by Inhibition in the Cerebellum.
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DOI：
10.1016/j.neuron.2018.07.024
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发表时间：
2018-09-05
期刊：
影响因子：
16.2
通讯作者：
Christie JM
中科院分区：
文献类型：
--
作者：
Rowan MJM;Bonnan A;Zhang K;Amat SB;Kikuchi C;Taniguchi H;Augustine GJ;Christie JM
Purkinje cell dendrites convert excitatory climbing fiber input into signals that instruct plasticity and motor learning. Modulation of instructive signaling may increase the range in which learning is encoded, yet the mechanisms that allow for this are poorly understood. We found that optogenetic activation of molecular layer interneurons (MLIs) that inhibit Purkinje cells suppressed climbing fiber-evoked dendritic Ca2+ spiking. Inhibitory suppression of Ca2+ spiking depended on the level of MLI activation and influenced the induction of associative synaptic plasticity, converting climbing fiber-mediated potentiation of parallel fiber-evoked responses into depression. In awake mice, optogenetic activation of floccular climbing fibers in association with head rotation produced an adaptive increase in the vestibulo-ocular reflex (VOR). However, when climbing fibers were co-activated with MLIs, adaptation occurred in the opposite direction, decreasing the VOR. Thus, MLIs can direct a continuous spectrum of plasticity and learning through their influence on Purkinje cell dendritic Ca2+ signaling. By linking inhibitory control of Purkinje cell dendritic Ca2+ signaling to alteration of plasticity and learning, Rowan et al. provide a mechanistic framework by which MLIs influence the ability of climbing fibers to instruct adaptive behavior in the cerebellum.
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DOI：
10.1523/jneurosci.1350-11.2011
发表时间：
2011-07-20
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
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作者：
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