Spectrum of disease and outcome in children with symptomatic congenital cytomegalovirus infection.
Spectrum of disease and outcome in children with symptomatic congenital cytomegalovirus infection.
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DOI：
10.1016/j.jpeds.2013.12.007
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发表时间：
2014-04
影响因子：
5.1
通讯作者：
Ross, Shannon A.
中科院分区：
文献类型：
--
作者：
Dreher, A. Mackenzie;Arora, Nitin;Fowler, Karen B.;Novak, Zdenek;Britt, William J.;Boppana, Suresh B.;Ross, Shannon A.
评价新生儿筛查（筛查组）和出生时基于临床结果（转诊组）确定的症状性先天性巨细胞病毒（cCMV）患儿的表现和结局差异。分析了178例有症状的cCMV婴儿的数据。使用χ2或Fisher精确检验比较筛选组和转诊组的人口统计学特征、托儿所记录的临床和实验室结果以及后遗症数据。91%的转诊婴儿在出生时检测到两种或两种以上的临床表现，而筛查婴儿仅为58%（p < 0.001）。与筛查婴儿相比，转诊组中有更多儿童患有听力损失（p = 0.009）。51%的筛查儿童没有后遗症，而转诊组只有28%（p < 0.003）。根据临床怀疑确定的有症状的cCMV婴儿在出生时的疾病更严重，并且比新生儿筛查中确定的婴儿更常见后遗症。由于选择偏倚，许多先前报告中纳入转诊婴儿可能高估了疾病的严重程度。定义cCMV引起的症状性疾病的完整谱并提供疾病负担的精确估计只能从大型新生儿筛查研究中收集。
To evaluate differences in presentation and outcomes in children with symptomatic congenital cytomegalovirus (cCMV) identified on newborn screening (screened group) and those identified based on clinical findings at birth (referred group). Data on 178 infants with symptomatic cCMV were analyzed. Demographic characteristics, clinical and laboratory findings documented in the nursery, and sequelae data were compared between the screened and the referred groups using χ2 or Fisher exact test. Two or more clinical findings were detected at birth in 91% of referred infants, and only 58% of screened infants (p < 0.001). Significantly more children in the referred group had hearing loss compared with screened infants (p = 0.009). Fifty-one percent of screened children were free of sequelae compared with only 28% of the referred group (p < 0.003). Infants with symptomatic cCMV identified based on clinical suspicion have more severe disease at birth and more commonly have sequelae than those identified on newborn screening. Inclusion of referral infants in many previous reports may have overestimated the severity of disease because of selection bias. Defining the complete spectrum of symptomatic disease due to cCMV and providing precise estimates of disease burden can only be gathered from large newborn screening studies.
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影响因子：
5.1
作者：
Noyola, DE;Demmler, GJ;Yow, MD
通讯作者：
Yow, MD
影响因子：
3.6
作者：
BOPPANA, SB;PASS, RF;ALFORD, CA
通讯作者：
ALFORD, CA
影响因子：
6.4
作者：
BALCAREK, KB;WARREN, W;PASS, RF
通讯作者：
PASS, RF
DOI：
10.1111/j.1469-7610.2007.01814.x
发表时间：
2007-12-01
影响因子：
7.6
作者：
McPhillips, Martin;Jordan-Black, Julie-Anne
通讯作者：
Jordan-Black, Julie-Anne
DOI：
10.1136/adc.2005.090308
发表时间：
2007-01-01
影响因子：
4.4
作者：
Smith, L. K.;Draper, E. S.;Field, D. J.
通讯作者：
Field, D. J.