Integrating phenotypic small-molecule profiling and human genetics: the next phase in drug discovery.
Integrating phenotypic small-molecule profiling and human genetics: the next phase in drug discovery.
复制标题
DOI：
10.1016/j.tig.2014.11.002
复制
发表时间：
2015-01
期刊：
影响因子：
--
通讯作者：
Wagner BK
中科院分区：
文献类型：
--
作者：
Johannessen CM;Clemons PA;Wagner BK
Over the past decade, tremendous progress in high-throughput small-molecule screening methods has facilitated the rapid expansion of phenotype-based data. Parallel advances in genomic characterization methods have complemented these efforts by providing a growing list of annotated cell line features. Together, these developments have paved the way for feature-based identification of novel, exploitable cellular dependencies, subsequently expanding our therapeutic toolkit in cancer and other diseases. Here, we provide an overview of the evolution of phenotypic small-molecule profiling and discuss the most significant and recent profiling and analytical efforts, their impact on the field, and their clinical ramifications. We additionally provide a perspective for future developments in phenotypic profiling efforts guided by genomic science.
登录
查看更多内容
影响因子：
11.2
作者：
Antony, Rajee;Emery, Caroline M.;Garraway, Levi A.
通讯作者：
Garraway, Levi A.
影响因子：
64.5
作者：
Basu A;Bodycombe NE;Cheah JH;Price EV;Liu K;Schaefer GI;Ebright RY;Stewart ML;Ito D;Wang S;Bracha AL;Liefeld T;Wawer M;Gilbert JC;Wilson AJ;Stransky N;Kryukov GV;Dancik V;Barretina J;Garraway LA;Hon CS;Munoz B;Bittker JA;Stockwell BR;Khabele D;Stern AM;Clemons PA;Shamji AF;Schreiber SL
通讯作者：
Schreiber SL
影响因子：
--
作者：
Brunelli L;Caiola E;Marabese M;Broggini M;Pastorelli R
通讯作者：
Pastorelli R
影响因子：
--
作者：
Dančík V;Carrel H;Bodycombe NE;Seiler KP;Fomina-Yadlin D;Kubicek ST;Hartwell K;Shamji AF;Wagner BK;Clemons PA
通讯作者：
Clemons PA
影响因子：
4.5
作者：
Choy E;Yelensky R;Bonakdar S;Plenge RM;Saxena R;De Jager PL;Shaw SY;Wolfish CS;Slavik JM;Cotsapas C;Rivas M;Dermitzakis ET;Cahir-McFarland E;Kieff E;Hafler D;Daly MJ;Altshuler D
通讯作者：
Altshuler D