Incidence and Characteristics of Nonfatal Opioid Overdose Among Youths Aged 11 to 24 Years by Sex.
Incidence and Characteristics of Nonfatal Opioid Overdose Among Youths Aged 11 to 24 Years by Sex.
复制标题
性别11至24岁的年轻人中非致命阿片类药物过量的发病率和特征。
DOI：
10.1001/jamanetworkopen.2020.30201
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发表时间：
2020-12-01
影响因子：
13.8
通讯作者：
Barocas JA
中科院分区：
文献类型：
--
作者：
Bagley SM;Gai MJ;Earlywine JJ;Schoenberger SF;Hadland SE;Barocas JA
本队列研究比较了经历过非致命性阿片类药物过量的美国年轻人的社会人口学和临床特征，并按性别检查了非致命性阿片类药物过量的发生率。在经历非致命性阿片类药物过量的青少年中，社会人口学、临床特征和发生率是否存在性别差异？在这项队列研究中，20312名11至24岁的美国商业保险青年经历过非致命性阿片类药物过量，女性青年有更高的基线焦虑、抑郁和自残史患病率；男性青年在其他物质使用障碍方面的基线患病率较高。在11至16岁的人群中，女性青年的非致命性阿片类药物过量发生率明显高于男性青年；17岁以后，男性青少年的发病率高于女性青少年。该研究发现女性和男性青年在社会人口学和临床特征以及非致命性阿片类药物过量发生率方面存在差异，这表明需要制定量身定制的策略来解决这一人群的过量问题。近年来，阿片类药物过量在青少年和年轻人中大幅增加。青少年用药过量在年龄和性别上的差异以及与性别用药过量相关的因素仍然缺乏描述。比较经历过非致命性阿片类药物过量（NFOD）的女性和男性青年的社会人口学和临床特征，并按性别比较NFOD的发病率。这项回顾性队列研究使用了2006年1月1日至2017年12月31日期间IBM MarketScan商业数据库中11至24岁诊断为NFOD的美国个体的数据。性。主要结局是按性别划分的非功能性fod；协变量包括社会人口学和临床特征。20312名11 ~ 24岁有非功能性fod病史且符合研究资格标准的青少年中，年龄中位数为20岁（四分位间距18 ~ 22岁，平均[SD]年龄20.0[2.9]岁），56.7%为男性。与男性青年相比，女性青年的情绪或焦虑障碍基线患病率更高（65.5% vs 51.9%, P < 0.05）。001)，创伤和应激相关障碍（16.4% vs 10.1%, P < 0.001）。有自杀企图或自残史（14.6% vs 9.9%, P < 0.001）。男性青年阿片类药物使用障碍患病率较高（44.7% vs 29.2%, P < 0.05）。001)，大麻使用障碍(18.3% vs 11.3%, P <。和酒精使用障碍（20.3% vs 14.4%, P < 0.001）。11至16岁女性与男性的非功能性残疾发病率比大于1,17岁后小于等于1。这项队列研究发现了男女青年在社会人口学、临床特征和非残障发生率方面的差异。尽管经历过量的女性和男性青年似乎有不同的风险因素，但其中许多风险因素可以通过筛查和干预及早发现。
This cohort study compares the sociodemographic and clinical characteristics of US youths who have experienced a nonfatal opioid overdose and examines the incidence of nonfatal opioid overdose by sex. Among youths who experience nonfatal opioid overdose, are there differences by sex in sociodemographic and clinical characteristics and incidence of occurrence? In this cohort study of 20 312 commercially insured US youths aged 11 to 24 years who experienced nonfatal opioid overdose, female youths had a higher prevalence of baseline anxiety, depression, and history of self-harm; male youths had a higher baseline prevalence of other substance use disorders. Among those aged 11 to 16 years, female youths experienced a significantly greater incidence of nonfatal opioid overdose than male youths; after age 17 years, the incidence became greater for male youths than for female youths. This study found differences between female and male youths in sociodemographic and clinical characteristics and incidence of nonfatal opioid overdose, suggesting a need for tailored strategies to address overdose in this population. Opioid-related overdose has substantially increased among adolescents and young adults in recent years. How overdose differs by age and sex among youths and the factors associated with overdose by sex remain poorly described. To compare the sociodemographic and clinical characteristics of female and male youths who have experienced a nonfatal opioid overdose (NFOD) and compare the incidence of NFOD by sex. This retrospective cohort study used data on US individuals aged 11 to 24 years with a diagnosis of NFOD from the IBM MarketScan Commercial Database from January 1, 2006, through December 31, 2017. Sex. The primary outcome was NFOD stratified by sex; covariates included sociodemographic and clinical characteristics. Among 20 312 youths aged 11 to 24 years who had a history of NFOD and met study eligibility criteria, the median age was 20 years (interquartile range, 18-22 years; mean [SD] age, 20.0 [2.9] years) and 56.7% were male. Compared with male youths, female youths had a higher baseline prevalence of mood or anxiety disorder (65.5% vs 51.9%, P < .001), trauma and stress-related disorders (16.4% vs 10.1%, P < .001), and history of suicide attempt or self-harm (14.6% vs 9.9%, P < .001). Male youths had a higher prevalence of opioid use disorder (44.7% vs 29.2%, P < .001), cannabis use disorder (18.3% vs 11.3%, P < .001), and alcohol use disorder (20.3% vs 14.4%, P < .001). The incidence rate ratio of NFODs in females vs males was greater than 1 for ages 11 to 16 years and was less than or equal to 1 after age 17 years. This cohort study found differences between female and male youths in sociodemographic and clinical characteristics and incidence of NFOD. Although female and male youths who experience overdose appear to have different risk factors, many of these risk factors may be amenable to early detection through screening and intervention.
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