Hantaviruses. a short review.
Hantaviruses. a short review.
复制标题
汉坦病毒属。
DOI：
--
复制
发表时间：
2003
影响因子：
4.6
通讯作者：
J. Lednicky
中科院分区：
文献类型：
--
作者：
J. Lednicky
目标
汉坦病毒是一种啮齿类病毒，已被确定为两种人类疾病的病原体：肾综合征出血热（HFRS）和汉坦病毒肺综合征（HPS）。本文简要介绍了汉坦病毒的生物学，HFRS和HPS的医学特征，以及检测人类汉坦病毒感染的检测方法。
资料综合
肾综合征出血热是一种在美洲以外发现的疾病，是一组临床上相似的疾病，其严重程度因病原体而异。汉坦病毒肺综合征与比HFRS更高的死亡率相关，于1993年首次被确认为汉坦病毒病，并发生在美洲大陆。最近的遗传学研究表明，旧世界和新世界的汉他病毒物种与特定的啮齿动物宿主共同进化。与HPS相关的不同汉坦病毒的列表正在增加。随着越来越多的土地被清理用于商业和住宅目的，人口的迅速增长正在破坏自然栖息地。许多啮齿动物很容易适应人类住区的生活，在那里它们通常会从减少捕食中受益，有时会繁殖到大量。
结论
虽然通常被称为新兴病原体，但HPS相关汉坦病毒是通过人类接触啮齿动物及其排泄物的增加而出现的，而不是通过病毒基因组的遗传漂变或重组。根据目前的人口增长和发展趋势，汉坦病毒疾病将在不久的将来变得更加普遍，除非采取公共卫生措施减少或消除人类社区的啮齿动物。
OBJECTIVES
Hantaviruses are rodent viruses that have been identified as etiologic agents of 2 diseases of humans: hemorrhagic fever with renal syndrome (HFRS) and hantavirus pulmonary syndrome (HPS). This article presents a concise review of hantavirus biology, the medical features of HFRS and HPS, and tests for the detection of hantavirus infections in humans.
DATA SYNTHESIS
Hemorrhagic fever with renal syndrome is a disease found outside the Americas and denotes a group of clinically similar illnesses that vary in severity relative to the causative agent. Hantavirus pulmonary syndrome is associated with higher mortality than HFRS, was first recognized as a hantavirus disease in 1993, and occurs within the American continents. Recent genetic studies show that both Old and New World hantavirus species coevolved with specific rodent hosts. The list of distinct hantaviruses associated with HPS is growing. The burgeoning human population is causing disruption of natural habitats as more and more land is cleared for commercial and residential purposes. Many rodents readily adapt to life in human settlements, where they generally benefit from reduced predation and where they sometimes proliferate to high numbers.
CONCLUSIONS
Although often referred to as emerging pathogens, HPS-associated hantaviruses emerge through increased exposure of humans to rodents and their excreta, not through genetic drift or reassortment of the viral genome. Based on current human population growth and development trends, hantavirus diseases will become more common in the near future unless public health measures are taken to curtail or eliminate rodents from human communities.
影响因子：
6
作者：
S. Zaki;P. Greer;L. Coffield;C. Goldsmith;K. B. Nolte;K. Foucar;R. Feddersen;R. Zumwalt;G. Miller;Ali S Khan;P. Rollin;T. Ksiazek;S. Nichol;B. Mahy;C. Peters
通讯作者：
S. Zaki;P. Greer;L. Coffield;C. Goldsmith;K. B. Nolte;K. Foucar;R. Feddersen;R. Zumwalt;G. Miller;Ali S Khan;P. Rollin;T. Ksiazek;S. Nichol;B. Mahy;C. Peters
自然感染致病性 NY-1 汉坦病毒的白鼠白鼠的组织病理学：小鼠 HPS 病毒感染的病理标志物。
DOI：
--
发表时间：
1996
期刊：
Laboratory investigation; a journal of technical methods and pathology.
影响因子：
--
作者：
Lyubsky,S;Gavrilovskaya,I;Luft,B;Mackow,E
通讯作者：
Mackow,E
DOI：
10.4269/ajtmh.1996.55.672
发表时间：
1996-12-01
影响因子：
3.3
作者：
Rawlings, JA;TorrezMartinez, N;Hjelle, B
通讯作者：
Hjelle, B