Periodontal inflamed surface area in oral cavity associated with febrile neutropenia in patients with hematologic malignancy undergoing chemotherapy.
Periodontal inflamed surface area in oral cavity associated with febrile neutropenia in patients with hematologic malignancy undergoing chemotherapy.
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DOI：
10.1038/s41598-022-06485-0
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发表时间：
2022-02-15
影响因子：
4.6
通讯作者：
Kawaguchi H
中科院分区：
文献类型：
--
作者：
Nishi H;Ohta K;Kuramoto Y;Shigeishi H;Obayashi T;Yoshioka Y;Konishi M;Munenaga S;Nagoshi H;Yoshida T;Fukushima N;Kakimoto N;Ohge H;Kurihara H;Ichinohe T;Kawaguchi H
发热性中性粒细胞减少症（FN）是化疗期间发生的感染性并发症。虽然口腔可能是重要的感染途径，但尚不清楚口腔环境是否与FN相关。本研究使用牙周炎表面积（比萨），一个新的牙周疾病参数，和FN的血液癌症患者接受化疗的口腔环境之间的关系进行了研究。在这项回顾性队列研究中，157例患者分为化疗期间FN发作组（n = 75）和FN阴性组（n = 82）。评估了与口腔内环境相关的风险因素的相关性。Logistic回归分析显示，血癌类型（比值比1.98; P < 0.01），使用高风险方案（比值比4.44; P < 0.05），用人粒细胞集落刺激因子（G-CSF）预防治疗（OR 4.15; P < 0.01）和比萨（OR 1.02; P < 0.01）是FN发病的独立相关因素。最后，在两组之间进行倾向评分匹配;生成37个匹配对。FN组的比萨评分显著高于FN阴性组。比萨阳性率与FN发病率有显著相关性（P = 0.035）。目前的研究结果表明，牙周炎治疗开始癌症治疗之前，建议作为支持性护理，以防止FN在化疗期间发作。
Febrile neutropenia (FN) is an infectious complication that develops during chemotherapy. Although the oral cavity can be an important infection route, it is unknown whether the oral environment is associated with FN. The present study examined the relationship between the oral environment using periodontal inflamed surface area (PISA), a new periodontal disease parameter, and FN in hematologic cancer patients undergoing chemotherapy. In this retrospective cohort study, 157 patients were divided into FN onset during chemotherapy (n = 75) and the FN negative groups (n = 82). The associations of risk factors related to the intraoral environment were assessed. Logistic regression analysis showed that types of blood cancer (odds ratio 1.98; P < 0.01), use of a high-risk regimen (odds ratio 4.44; P < 0.05), prophylaxis treatment with human granulocyte colony-stimulating factor (G-CSF) (odds ratio 4.15; P < 0.01) and PISA (odds ratio 1.02; P < 0.01) were independent factors associated with FN onset. Finally, propensity score matching was performed between two groups; 37 matched pairs were generated. PISA was significantly higher in the FN group than the FN negative group. There was a significant relationship between PISA and FN onset (P = 0.035). The present findings indicate that periodontitis treatment before starting cancer treatment is recommended as supportive care for preventing FN onset during chemotherapy.
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影响因子：
50.5
作者：
Klastersky, J.;de Naurois, J.;Herrstedt, J.
通讯作者：
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影响因子：
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通讯作者：
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影响因子：
6.7
作者：
LANG, NP;ADLER, R;NYMAN, S
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NYMAN, S