Differential patterns of contextual organization of memory in first-episode psychosis.
Differential patterns of contextual organization of memory in first-episode psychosis.
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DOI：
10.1038/s41537-018-0046-8
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发表时间：
2018-02-15
影响因子：
5.4
通讯作者：
Luna B
中科院分区：
文献类型：
--
作者：
Murty VP;McKinney RA;DuBrow S;Jalbrzikowski M;Haas GL;Luna B
Contextual information is used to support and organize episodic memory. Prior research has reliably shown memory deficits in psychosis; however, little research has characterized how this population uses contextual information during memory recall. We employed an approach founded in a computational framework of free recall to quantify how individuals with first episode of psychosis (FEP, N = 97) and controls (CON, N = 55) use temporal and semantic context to organize memory recall. Free recall was characterized using the Hopkins Verbal Learning Test-Revised (HVLT-R). We compared FEP and CON on three measures of free recall: proportion recalled, temporal clustering, and semantic clustering. Measures of temporal/semantic clustering quantified how individuals use contextual information to organize memory recall. We also assessed to what extent these measures relate to antipsychotic use and differentiated between different types of psychosis. We also explored the relationship between these measures and intelligence. In comparison to CON, FEP had reduced recall and less temporal clustering during free recall (p < 0.05, Bonferroni-corrected), and showed a trend towards greater semantic clustering (p = 0.10, Bonferroni-corrected). Within FEP, antipsychotic use and diagnoses did not differentiate between free recall accuracy or contextual organization of memory. IQ was related to free recall accuracy, but not the use of contextual information during recall in either group (p < 0.05, Bonferroni-corrected). These results show that in addition to deficits in memory recall, FEP differed in how they organize memories compared to CON. First-episode psychosis patients exhibit impaired memory recall and deviation in how context is used to support recall ability. A US team of researchers led by the University of Pittsburgh’s Vishnu Murty examined how FEP affects an individual’s ability to organize memory based on context, by noting how well patients could recall words from a spoken list. Alongside recollection accuracy, Murty’s team assesed participant ability to recall words said proximally in sequence, and the ability to recall words from the same category—measuring ‘temporal clustering’ and ‘semantic clustering.’ The researchers found that patients with FEP had reduced recall ability and less temporal clustering. Recall accuracy and IQ were also found to be related. This study increases knowledge of FEP-related cognitive changes and could help to target specific therapies.
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影响因子：
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作者：
Bornstein AM;Daw ND
通讯作者：
Daw ND
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作者：
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Kahana, MJ
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Pilowsky, LS
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