Assisted reproduction technologies impair placental steroid metabolism.
Assisted reproduction technologies impair placental steroid metabolism.
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DOI：
10.1016/j.jsbmb.2009.04.005
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发表时间：
2009-08
影响因子：
4.1
通讯作者：
Ward, Monika A.
中科院分区：
文献类型：
--
作者：
Collier, Abby C.;Miyagi, Shogo J.;Yamauchi, Yasuhiro;Ward, Monika A.
The placenta plays a vital role in pregnancy by facilitating steroid passage from maternal to fetal circulation and/or direct production of hormones. Using a murine model, we demonstrated the differences in placental steroid metabolism between pregnancies conceived naturally and with assisted reproduction technologies (ART): in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI). While the ovarian steroid production was similar (estrone, 17β-estradiol) or higher (estriol) in ART pregnancies compared to mating, the levels of placental estriol were significantly lower in ART group. Placentas from ART had significantly higher activities of the steroid metabolizing enzymes UDP-glucuronosyltransferase (UGT) and sulfotransferase (SULT), which in ICSI were also coupled with decreased activity of the steroid regenerating enzymes β-glucuronidase (β-G) and Aryl sulfatase (AS). Levels of steroid metabolites androstane-3α-17β-diol glucuronide and dehydroepiandrosterone sulfate were higher in fetal compared to maternal blood in ART, but not in mating. This study demonstrates that in murine ART pregnancies, higher metabolism and clearance of steroids by the placenta may seriously affect the passage of essential hormones to the fetus. If a similar phenomenon exists in humans, this could provide a plausible explanation for obstetric and neonatal complications associated with ART, including the higher incidence of low birth weight babies.
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影响因子：
6.1
作者：
Collier, AC;Tingle, MD;Keelan, JA
通讯作者：
Keelan, JA
影响因子：
3.6
作者：
KIMURA, Y;YANAGIMACHI, R
通讯作者：
YANAGIMACHI, R
DOI：
10.1111/j.1471-0528.2005.00745.x
发表时间：
2005-11-01
影响因子：
5.8
作者：
Källén, B;Finnström, O;Wennerholm, UB
通讯作者：
Wennerholm, UB
影响因子：
6.6
作者：
Silver, RI;Rodriguez, R;Gearhart, JP
通讯作者：
Gearhart, JP
DOI：
10.1002/tcm.1770110104
发表时间：
1991-01-01
期刊：
TERATOGENESIS CARCINOGENESIS AND MUTAGENESIS
影响因子：
--
作者：
KRAFT, JC;ECKHOFF, C;NAU, H
通讯作者：
NAU, H