From a young BSJ member: advanced technologies encouraged me to dive into biophysics field
From a young BSJ member: advanced technologies encouraged me to dive into biophysics field
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来自年轻BSJ成员：先进技术鼓励我深入生物物理领域
DOI：
10.1007/s12551-020-00648-x
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发表时间：
2020
影响因子：
--
通讯作者：
Kazuko Okamoto
中科院分区：
文献类型：
--
作者：
曽谷 実玖;大川 奈菜子;山本 真帆;堀江 健生;大沼 耕平;日下部 岳広;Kazuko Okamoto
我是冈本和子，在2018年开放的理研-广岛大学合作研究设施担任研究员。在过去的4年里，我一直致力于活核转录因子的单分子成像工作，以了解染色质结构与转录因子分子动力学之间的关系。我一直对生物物理领域发展中的显微镜技术着迷，包括单分子成像；因此，我开始用这样的显微镜研究转录因子的动力学。然后，我在3年前加入了日本生物物理学会(BSJ)，他们给了我一个机会在这里写下这篇评论，当时我还是BSJ的年轻成员。我在科学生涯的早期学习发育生物学，因此对生物物理学领域的技术和研究产生了隔阂。我从来没有想过，现在可以在单分子水平上观察包括转录因子在内的核蛋白，并获得活核内部的时空信息。
I am Kazuko Okamoto working as a researcher in RIKEN-Hiroshima University Collaboration Research Facility, which was opened in 2018. In the past 4 years, I have been working for single molecular imaging of transcription factors in living nuclei in order to understand the relationships between chromatin architecture and molecular dynamics of transcription factors. I have been fascinated by microscopy technology developing in biophysics field, including single molecular imaging; therefore, I started to study about the dynamics of transcription factors using such microscopes. Then, I joined The Biophysical Society of Japan (BSJ) 3 years ago, and they gave me a chance to write this commentary here as a young BSJ member.I studied developmental biology in the early days of my scientific career; thus, I was estranged in the techniques and studies in the biophysics field. I have never thought that it is now possible to observe nucleoproteins including transcription factors at single molecular level and obtain spatio-temporal information inside living nuclei in the past.
DOI：
10.1101/sqb.2015.80.027201
发表时间：
2015
期刊：
Cold Spring Harbor symposia on quantitative biology
影响因子：
--
作者：
Coleman RA;Liu Z;Darzacq X;Tjian R;Singer RH;Lionnet T
通讯作者：
Lionnet T
影响因子：
64.5
作者：
Ohno, Masae;Ando, Tadashi;Taniguchi, Yuichi
通讯作者：
Taniguchi, Yuichi