Candida auris Clinical Isolates Associated with Outbreak in Neonatal Unit of Tertiary Academic Hospital, South Africa.
Candida auris Clinical Isolates Associated with Outbreak in Neonatal Unit of Tertiary Academic Hospital, South Africa.
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DOI：
10.3201/eid2910.230181
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发表时间：
2023-10
影响因子：
11.8
通讯作者：
Govender, Nelesh P.
中科院分区：
文献类型：
--
作者：
Kekana, Dikeledi;Naicker, Serisha D.;Shuping, Liliwe;Velaphi, Sithembiso;Nakwa, Firdose L.;Wadula, Jeannette;Govender, Nelesh P.
2009年，在南非约翰内斯堡的一所大学附属医院首次发现了耳念珠菌。我们用全基因组测序技术描述了C. 2016年至2020年期间，同一家医院发生了耳炎;新生儿病房从2019年6月开始持续爆发。在287例经培养确诊的C.在通过实验室监测确定的耳感染中，207例（72%）有存活的分离株，188例（66%）进行了全基因组测序。分支III（118/188，63%）和IV（70/188，37%）分离株在医院中共循环。所有181/188株氟康唑MIC >32 µg/mL的分离株均存在ERG 11突变;进化枝III分离株具有VF 125 AL取代，进化枝IV分离株具有K177 R/N335 S/E343 D取代。以分支III为主，新生儿单位暴发占研究期间所有病例的32%（91/287）。疫情可能是通过感染或定植的患者、定植的医护人员或受污染的设备/环境传播的。
Candida auris was first detected at a university-affiliated hospital in Johannesburg, South Africa, in 2009. We used whole-genome sequencing to describe the molecular epidemiology of C. auris in the same hospital during 2016–2020; the neonatal unit had a persistent outbreak beginning in June 2019. Of 287 cases with culture-confirmed C. auris infection identified through laboratory surveillance, 207 (72%) had viable isolates and 188 (66%) were processed for whole-genome sequencing. Clade III (118/188, 63%) and IV (70/188, 37%) isolates co-circulated in the hospital. All 181/188 isolates that had a fluconazole MIC >32 µg/mL had ERG11 mutations; clade III isolates had VF125AL substitutions, and clade IV isolates had K177R/N335S/E343D substitutions. Dominated by clade III, the neonatal unit outbreak accounted for 32% (91/287) of all cases during the study period. The outbreak may have originated through transmission from infected or colonized patients, colonized healthcare workers, or contaminated equipment/environment.
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影响因子：
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作者：
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通讯作者：
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影响因子：
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影响因子：
13.2
作者：
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通讯作者：
Govender NP for GERMS-SA
影响因子：
34.3
作者：
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通讯作者：
Govender, Nelesh P.