The burden of Clostridioides difficile infection in COVID-19 patients: A systematic review and meta-analysis.
The burden of Clostridioides difficile infection in COVID-19 patients: A systematic review and meta-analysis.
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DOI：
10.1016/j.anaerobe.2021.102484
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发表时间：
2022-04
期刊：
影响因子：
2.3
通讯作者：
Cataldo MA
中科院分区：
文献类型：
--
作者：
Granata G;Petrosillo N;Al Moghazi S;Caraffa E;Puro V;Tillotson G;Cataldo MA
本系统性综述和荟萃分析的主要目的是评估确诊的COVID-19患者中艰难梭菌感染（CDI）的比例，并描述这些患者的风险因素和结局。检索了截至2021年7月15日的MEDLINE和科克伦对照试验中心注册数据库。我们纳入了报告确诊COVID-19患者发生CDI数据的研究。我们使用随机效应模型（DerSimonian-Laird方法）合并CDI患者的比例，使用Freeman-Tukey双反正弦变换稳定方差。13项研究被纳入系统综述。所有研究均回顾性收集了2020年2月至2021年2月期间的数据。报告的CDI发生率范围为1.4 - 4.4例CDI病例/10，000患者-天。7项研究报告了研究期间发生CDI的COVID-19患者数量和COVID-19患者总数的数据，并纳入荟萃分析，包括23，697名COVID-19患者。发生CDI的COVID-19患者的总体汇总比例为1% [95%置信区间：1-2]。在报告了COVID-19患者和非COVID-19患者发生CDI的研究中，大多数报告了与COVID前相比CDI率降低或不变。CDI是COVID-19患者的相关问题。即使在COVID-19大流行期间，遵守感染预防及控制措施以及抗菌药物管理原则亦至关重要。
The main aim of this systematic review and meta-analysis was to assess the proportion of confirmed COVID-19 patients with Clostridioides difficile infection (CDI) and to describe risk factors and outcome of these patients. MEDLINE and Cochrane Central Register of Controlled Trials databases were searched up to July 15, 2021. We included studies reporting data on CDI occurring in patients with a confirmed diagnosis of COVID-19. We pooled proportion of CDI patients using a random effects model (DerSimonian–Laird method) stabilising the variances using the Freeman-Tukey double arcsine transformation. Thirteen studies were included in the systematic review. All the studies retrospectively collected data between February 2020 and February 2021. The reported CDI incidence rates ranged from 1.4 to 4.4 CDI cases per 10,000 patient-days. Seven studies reported data on the number of COVID-19 patients who developed CDI and the total number of COVID-19 patients in the study period and were included in the meta-analysis, comprising 23,697 COVID-19 patients. The overall pooled proportion of COVID-19 patients who had CDI was 1% [95% confidence interval: 1–2]. Among studies reporting CDI occurrence in patients with and without COVID-19, the majority of them reported reduced or unchanged CDI rates compared to pre-COVID period. CDI is a relevant issue for COVID-19 patients. Adherence to infection prevention and control measures and to the antimicrobial stewardship principles is crucial even during the COVID-19 pandemic.
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影响因子：
168.9
作者：
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通讯作者：
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DOI：
10.20452/pamw.15715
发表时间：
2021-02-26
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