Differential regulation of skeletal stem/progenitor cells in distinct skeletal compartments.
Differential regulation of skeletal stem/progenitor cells in distinct skeletal compartments.
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DOI：
10.3389/fphys.2023.1137063
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发表时间：
2023
影响因子：
4
通讯作者：
Park, Dongsu
中科院分区：
文献类型：
--
作者：
Solidum, Jea Giezl Niedo;Jeong, Youngjae;Heralde III, Francisco;Park, Dongsu
关键词：
骨干/祖细胞（SSPCs）具有自我更新和多能性的特点，对骨骼发育、骨重建和骨修复至关重要。传统上已知这些细胞存在于骨髓中，但最近的研究已经确定了其他骨骼隔室（如生长板、骨膜和颅骨缝）中存在不同的SSPC群体。不同SSPC群体的细胞和基质环境的差异被认为调节其干性，并指导其在不同发育阶段、稳态和再生中的作用;胚胎起源和邻近组织结构的差异也影响SSPC调节。由于这些SSPC小生境是动态的和高度专业化的，在应力条件下的变化和老化可以改变细胞组成和分子机制的地方，有助于局部SSPC及其在骨再生的活性失调。因此，更好地了解每个骨骼隔室中不同SSPC在不同条件下的不同调节机制，可以为现有的知识差距提供答案，并推动其在生物和医学领域的潜力。在这里，我们总结了目前的科学进展，在不同的骨隔间不同SSPC的差异调节途径的研究。我们还讨论了物理，生物和分子因素，影响每个骨骼隔间生态位。最后，我们研究了衰老如何影响SSPC的再生能力。了解这些调节差异可以为发现颅骨或长骨修复的新治疗方法开辟新途径。
Skeletal stem/progenitor cells (SSPCs), characterized by self-renewal and multipotency, are essential for skeletal development, bone remodeling, and bone repair. These cells have traditionally been known to reside within the bone marrow, but recent studies have identified the presence of distinct SSPC populations in other skeletal compartments such as the growth plate, periosteum, and calvarial sutures. Differences in the cellular and matrix environment of distinct SSPC populations are believed to regulate their stemness and to direct their roles at different stages of development, homeostasis, and regeneration; differences in embryonic origin and adjacent tissue structures also affect SSPC regulation. As these SSPC niches are dynamic and highly specialized, changes under stress conditions and with aging can alter the cellular composition and molecular mechanisms in place, contributing to the dysregulation of local SSPCs and their activity in bone regeneration. Therefore, a better understanding of the different regulatory mechanisms for the distinct SSPCs in each skeletal compartment, and in different conditions, could provide answers to the existing knowledge gap and the impetus for realizing their potential in this biological and medical space. Here, we summarize the current scientific advances made in the study of the differential regulation pathways for distinct SSPCs in different bone compartments. We also discuss the physical, biological, and molecular factors that affect each skeletal compartment niche. Lastly, we look into how aging influences the regenerative capacity of SSPCs. Understanding these regulatory differences can open new avenues for the discovery of novel treatment approaches for calvarial or long bone repair.
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影响因子：
5.2
作者：
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影响因子：
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通讯作者：
Weissman, Irving L.
影响因子：
7.8
作者：
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通讯作者：
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