A Decline and Age Shift in Malaria Incidence in Rural Mali following Implementation of Seasonal Malaria Chemoprevention and Indoor Residual Spraying.
A Decline and Age Shift in Malaria Incidence in Rural Mali following Implementation of Seasonal Malaria Chemoprevention and Indoor Residual Spraying.
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DOI：
10.4269/ajtmh.20-0622
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发表时间：
2021-03-01
期刊：
影响因子：
--
通讯作者：
Thera MA
中科院分区：
文献类型：
--
作者：
Coulibaly D;Guindo B;Niangaly A;Maiga F;Konate S;Kodio A;Diallo A;Antar ATM;Kone AK;Traore K;Travassos MA;Sagara I;Doumbo OK;Thera MA
许多非洲国家报告说，由于实施控制战略，疟疾发病率有所下降。在马里，2004年引入了以青蒿素为基础的联合疗法，自2007年以来部分免费分发了长效驱虫蚊帐。在马里的Bandiagara镇，2009年至2013年进行的一项研究表明，尽管实施了以青蒿素为基础的联合疗法和疟疾防治方案，但与1999年相比，疟疾发病率保持稳定。自2016年以来，在全国范围内扩大了季节性疟疾化学预防。除了这些战略之外，2017年和2018年，Bandiagara的人口还受益于室内残留喷洒，并继续普遍覆盖蚊帐。鉴于最近控制策略的扩大，这项研究旨在测量Bandiagara的疟疾发病率。从2017年10月到2018年12月，对300名6个月至15岁的儿童进行了随访。我们每月进行横断面调查，通过显微镜测量贫血和疟疾感染的流行程度。有症状疟疾的总发病率为0.5次/人年。自2012年和1999年以来，5岁以下儿童的疟疾发病率显著下降（发病率比估计分别为6.7 [95% CI: 4.2-11.4]和13.5 [95% CI: 8.4-22.7]）。疟疾寄生虫病平均流行率为6.7%。5岁以上儿童的疟疾发病率高于5岁以下儿童，突出表明需要将疟疾控制工作扩大到这些年龄较大的儿童。
Many African countries have reported declines in malaria incidence, attributed to the implementation of control strategies. In Mali, artemisinin-based combination therapy (ACT) was introduced in 2004, and long-lasting insecticide-treated nets (LLINs) have been partially distributed free of charge since 2007. In the Malian town of Bandiagara, a study conducted from 2009 to 2013 showed a stable incidence of malaria compared with 1999, despite the implementation of ACTs and LLINs. Since 2016, seasonal malaria chemoprevention has been scaled up across the country. In addition to these strategies, the population of Bandiagara benefited from indoor residual spray implementation in 2017 and 2018 and continued universal bed net coverage. This study aimed to measure the incidence of malaria in Bandiagara, given this recent scaling up of control strategies. A cohort of 300 children aged 6 months to 15 years was followed up from October 2017 to December 2018. We performed monthly cross-sectional surveys to measure anemia and the prevalence of malaria infection by microscopy. The overall incidence of symptomatic malaria was 0.5 episodes/person-year. Malaria incidence in children up to 5 years old significantly declined since 2012 and since 1999 (incidence rate ratio estimates: 6.7 [95% CI: 4.2–11.4] and 13.5 [95% CI: 8.4–22.7]), respectively. The average prevalence of malaria parasitemia was 6.7%. Malaria incidence was higher in children older than 5 years than in those younger than 5 years, highlighting the need to extend malaria control efforts to these older children.
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影响因子：
3
作者：
White NJ
通讯作者：
White NJ
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3
作者：
Deribew A;Dejene T;Kebede B;Tessema GA;Melaku YA;Misganaw A;Gebre T;Hailu A;Biadgilign S;Amberbir A;Yirsaw BD;Abajobir AA;Shafi O;Abera SF;Negussu N;Mengistu B;Amare AT;Mulugeta A;Mengistu B;Tadesse Z;Sileshi M;Cromwell E;Glenn SD;Deribe K;Stanaway JD
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Stanaway JD
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3
作者：
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Thera, Mahamadou A.
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作者：
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影响因子：
3
作者：
Kayentao K;Florey LS;Mihigo J;Doumbia A;Diallo A;Koné D;Doumbo O;Eckert E
通讯作者：
Eckert E