Anaemia and malaria.

Anaemia and malaria.
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DOI:
10.1186/s12936-018-2509-9
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发表时间:
2018-10-19
期刊:
影响因子:
3
通讯作者:
White NJ
White NJ
中科院分区:
医学3区
文献类型:
--
作者:
White NJ

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疟疾是热带地区贫血的一个主要原因。疟疾感染导致受感染和未受感染的红细胞溶血和骨髓造血障碍,妨碍贫血的快速恢复。在疟疾高传播地区,几乎所有婴幼儿以及许多年龄较大的儿童和成人的血红蛋白浓度都因此降低。在这些地区,需要输血的严重危及生命的疟疾贫血症是幼儿住院的主要原因,特别是在疟疾传播最严重的雨季。在严重疟疾中,死亡率在入院血红蛋白3 g/dL以下急剧上升,但当血红蛋白浓度接近正常范围时,死亡率也会增加。在严重疟疾的管理中,输血阈值仍然不确定。通过控制病媒、部署驱虫蚊帐、及时准确诊断疾病和适当使用有效抗疟疾药物来预防疟疾,可大大减轻热带国家的贫血负担。
Malaria is a major cause of anaemia in tropical areas. Malaria infection causes haemolysis of infected and uninfected erythrocytes and bone marrow dyserythropoiesis which compromises rapid recovery from anaemia. In areas of high malaria transmission malaria nearly all infants and young children, and many older children and adults have a reduced haemoglobin concentration as a result. In these areas severe life-threatening malarial anaemia requiring blood transfusion in young children is a major cause of hospital admission, particularly during the rainy season months when malaria transmission is highest. In severe malaria, the mortality rises steeply below an admission haemoglobin of 3 g/dL, but it also increases with higher haemoglobin concentrations approaching the normal range. In the management of severe malaria transfusion thresholds remain uncertain. Prevention of malaria by vector control, deployment of insecticide-treated bed nets, prompt and accurate diagnosis of illness and appropriate use of effective anti-malarial drugs substantially reduces the burden of anaemia in tropical countries.
DOI: 10.4269/ajtmh.1995.53.547
发表时间: 1995-11-01
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