MiRNAs at the Crossroads between Innate Immunity and Cancer: Focus on Macrophages.
MiRNAs at the Crossroads between Innate Immunity and Cancer: Focus on Macrophages.
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DOI：
10.3390/cells7020012
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发表时间：
2018-02-08
期刊：
影响因子：
6
通讯作者：
Curtale G
中科院分区：
文献类型：
--
作者：
Curtale G
先天免疫细胞形成肿瘤微环境（TME）的整合组分，其可以控制或预防肿瘤的起始和进展，这是由于同时处理抗生长信号和促生长信号。这一决策过程是基因表达变化的结果，部分取决于转录后调控机制。在这种情况下，microRNA已被证明可以调节TME中特定肿瘤相关免疫细胞的募集和激活。这篇综述旨在描述靶向癌症相关先天免疫途径的最重要的microRNA。外泌体microRNA在肿瘤进展中的作用和基于microRNA的治疗策略也进行了讨论。
Innate immune cells form an integrative component of the tumor microenvironment (TME), which can control or prevent tumor initiation and progression, due to the simultaneous processing of both anti- and pro-growth signals. This decision-making process is a consequence of gene expression changes, which are in part dependent on post-transcriptional regulatory mechanisms. In this context, microRNAs have been shown to regulate both recruitment and activation of specific tumor-associated immune cells in the TME. This review aims to describe the most important microRNAs that target cancer-related innate immune pathways. The role of exosomal microRNAs in tumor progression and microRNA-based therapeutic strategies are also discussed.
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DOI：
10.4049/jimmunol.1202496
发表时间：
2013-06-15
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Banerjee S;Xie N;Cui H;Tan Z;Yang S;Icyuz M;Abraham E;Liu G
通讯作者：
Liu G
影响因子：
4.4
作者：
Almand, B;Clark, JI;Gabrilovich, DI
通讯作者：
Gabrilovich, DI
影响因子：
11.2
作者：
Chen S;Wang L;Fan J;Ye C;Dominguez D;Zhang Y;Curiel TJ;Fang D;Kuzel TM;Zhang B
通讯作者：
Zhang B
影响因子：
12.7
作者：
Cantoni C;Cignarella F;Ghezzi L;Mikesell B;Bollman B;Berrien-Elliott MM;Ireland AR;Fehniger TA;Wu GF;Piccio L
通讯作者：
Piccio L
影响因子：
11.2
作者：
Bunt, Stephanie K.;Yang, Linglin;Ostrand-Rosenberg, Suzanne
通讯作者：
Ostrand-Rosenberg, Suzanne