The hypothalamic-pituitary-adrenal axis as a substrate for stress resilience: Interactions with the circadian clock.
The hypothalamic-pituitary-adrenal axis as a substrate for stress resilience: Interactions with the circadian clock.
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DOI：
10.1016/j.yfrne.2019.100819
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发表时间：
2020-01
影响因子：
7.4
通讯作者：
Karatsoreos IN
中科院分区：
文献类型：
--
作者：
Kinlein SA;Karatsoreos IN
下丘脑-垂体-肾上腺 (HPA) 轴参与整个大脑和身体的生物通路，促进对不断变化的环境需求的适应和生存。当这些途径不再以最佳状态发挥作用时，对环境挑战的适应就会受到影响。 HPA 轴功能影响压力适应和恢复力的生理和行为机制尚未完全阐明。我们对应激生物学和疾病的理解必须考虑内分泌系统、神经回路和行为应对策略之间复杂的相互作用。此外，必须进一步考虑生理学其他方面的影响，包括生物钟，它对于调节 HPA 活动的日常变化至关重要。在增加复杂性的同时，它也提供了干预目标。了解 HPA 功能在调节这些不同的生物反应中的作用将为我们提供关于如何支持成功的压力适应和提高压力恢复能力的重要见解。
Thr hypothalamic-pituitary-adrenal (HPA) axis, engages biological pathways throughout the brain and body which promote adaptation and survival to changing environmental demands. Adaptation to environmental challenges is compromised when these pathways are no longer functioning optimally. The physiological and behavioral mechanisms through which HPA axis function influences stress adaptation and resilience are not fully elucidated. Our understanding of stress biology and disease must take into account the complex interactions between the endocrine system, neural circuits, and behavioral coping strategies. In addition, further consideration must be taken concerning influences of other aspects of physiology, including the circadian clock which is critical for regulation of daily changes in HPA activity. While adding a layer of complexity, it also offers targets for intervention. Understanding the role of HPA function in mediating these diverse biological responses will lead to important insights about how to bolster successful stress adaptation and promote stress resilience.
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