CD90 determined two subpopulations of glioma-associated mesenchymal stem cells with different roles in tumour progression.
CD90 determined two subpopulations of glioma-associated mesenchymal stem cells with different roles in tumour progression.
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CD90确定了胶质瘤相关间充质干细胞的两个亚群，在肿瘤进展中具有不同的作用
DOI：
10.1038/s41419-018-1140-6
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发表时间：
2018-10-27
影响因子：
9
通讯作者：
Fu P
中科院分区：
文献类型：
--
作者：
Zhang Q;Yi DY;Xue BZ;Wen WW;Lu YP;Abdelmaksou A;Sun MX;Yuan DT;Zhao HY;Xiong NX;Xiang W;Fu P
人胶质瘤相关间充质干细胞（gbMSCs）是恶性胶质瘤发生的基质细胞成分。最近的研究表明，gbMSCs由两个不同的亚群组成（CD90+和CD90− gbMSCs）。然而，在胶质瘤进展中的不同作用尚未阐明。在这项研究中，我们发现gbMSC在胶质瘤进展中的不同作用与CD 90表达相关。CD90高gbMSCs主要通过增加增殖、迁移和粘附显著驱动胶质瘤进展，而CD90低gbMSCs主要通过向周细胞转化和通过血管内皮细胞刺激血管形成促进胶质瘤进展。此外，在这两个gbMSC亚群中证实了长链非编码RNA和mRNA表达的差异，并讨论了潜在的潜在分子机制。我们的数据首次证实了CD90high和CD90low gbMSCs在人脑胶质瘤进展中发挥不同的作用。这些结果提供了新的见解，未来可能使用的战略，针对胶质瘤患者的gbMSC亚群。
Human glioma-associated mesenchymal stem cells (gbMSCs) are the stromal cell components that contribute to the tumourigenesis of malignant gliomas. Recent studies have shown that gbMSCs consist of two distinct subpopulations (CD90+ and CD90− gbMSCs). However, the different roles in glioma progression have not been expounded. In this study, we found that the different roles of gbMSCs in glioma progression were associated with CD90 expression. CD90high gbMSCs significantly drove glioma progression mainly by increasing proliferation, migration and adhesion, where as CD90low gbMSCs contributed to glioma progression chiefly through the transition to pericytes and stimulation of vascular formation via vascular endothelial cells. Furthermore, discrepancies in long non-coding RNAs and mRNAs expression were verified in these two gbMSC subpopulations, and the potential underlying molecular mechanism was discussed. Our data confirm for the first time that CD90high and CD90low gbMSCs play different roles in human glioma progression. These results provide new insights into the possible future use of strategies targeting gbMSC subpopulations in glioma patients.
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影响因子：
7.5
作者：
Pacioni S;D'Alessandris QG;Giannetti S;Morgante L;Coccè V;Bonomi A;Buccarelli M;Pascucci L;Alessandri G;Pessina A;Ricci-Vitiani L;Falchetti ML;Pallini R
通讯作者：
Pallini R
影响因子：
5.1
作者：
Iser, Isabele C.;Ceschini, Stefanie M.;Wink, Marcia R.
通讯作者：
Wink, Marcia R.
影响因子：
8.8
作者：
Nagasaki, T.;Hara, M.;Nakanishi, H.;Takahashi, H.;Sato, M.;Takeyama, H.
通讯作者：
Takeyama, H.
影响因子：
15.9
作者：
Shahar, Tal;Rozovski, Uri;Lang, Frederick F.
通讯作者：
Lang, Frederick F.
影响因子：
4.5
作者：
Campioni, D.;Lanza, F.;Cuneo, A.
通讯作者：
Cuneo, A.