Modification of the association between PM10 and lung function decline by cadherin 13 polymorphisms in the SAPALDIA cohort: a genome-wide interaction analysis.
Modification of the association between PM10 and lung function decline by cadherin 13 polymorphisms in the SAPALDIA cohort: a genome-wide interaction analysis.
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DOI：
10.1289/ehp.1307398
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发表时间：
2015-01
影响因子：
10.4
通讯作者：
Probst-Hensch NM
中科院分区：
文献类型：
--
作者：
Imboden M;Kumar A;Curjuric I;Adam M;Thun GA;Haun M;Tsai MY;Pons M;Bettschart R;Turk A;Rochat T;Künzli N;Schindler C;Kronenberg F;Probst-Hensch NM
Background: Both air pollution and genetic variation have been shown to affect lung function. Their interaction has not been studied on a genome-wide scale to date. Objectives: We aimed to identify, in an agnostic fashion, genes that modify the association between long-term air pollution exposure and annual lung function decline in an adult population-based sample. Methods: A two-stage genome-wide interaction study was performed. The discovery (n = 763) and replication (n = 3,896) samples were derived from the multi-center SAPALDIA cohort (Swiss Cohort Study on Air Pollution and Lung Disease in Adults). Annual rate of decline in the forced mid-expiratory flow (FEF25–75%) was the main end point. Multivariate linear regression analyses were used to identify potential multiplicative interactions between genotypes and 11-year cumulative PM10 exposure. Results: We identified a cluster of variants intronic to the CDH13 gene as the only locus with genome-wide significant interactions. The strongest interaction was observed for rs2325934 (p = 8.8 × 10–10). Replication of the interaction between this CDH13 variant and cumulative PM10 exposure on annual decline in FEF25–75% was successful (p = 0.008). The interaction was not sensitive to adjustment for smoking or body weight. Conclusions: CDH13 is functionally linked to the adipokine adiponectin, an inflammatory regulator. Future studies need to confirm the interaction and assess how the result relates to previously observed interactions between air pollution and obesity on respiratory function. Citation: Imboden M, Kumar A, Curjuric I, Adam M, Thun GA, Haun M, Tsai MY, Pons M, Bettschart R, Turk A, Rochat T, Künzli N, Schindler C, Kronenberg F, Probst-Hensch NM. 2015. Modification of the association between PM10 and lung function decline by cadherin 13 polymorphisms in the SAPALDIA cohort: a genome-wide interaction analysis. Environ Health Perspect 123:72–79; http://dx.doi.org/10.1289/ehp.1307398
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影响因子：
7.7
作者：
Chung CM;Lin TH;Chen JW;Leu HB;Yang HC;Ho HY;Ting CT;Sheu SH;Tsai WC;Chen JH;Lin SJ;Chen YT;Pan WH
通讯作者：
Pan WH
DOI：
10.1007/s00038-005-4075-5
发表时间：
2005-01-01
期刊：
SOZIAL-UND PRAVENTIVMEDIZIN
影响因子：
--
作者：
Ackermann-Liebrich, U;Kuna-Dibbert, B;Leuenberger, P
通讯作者：
Leuenberger, P
影响因子：
9.8
作者：
Jee, Sun Ha;Sull, Jae Woong;Beaty, Terri H.
通讯作者：
Beaty, Terri H.
DOI：
10.1186/1476-7961-4-9
发表时间：
2006-06-07
期刊：
Clinical and molecular allergy : CMA
影响因子：
--
作者：
Imboden, M;Nieters, A;Probst-Hensch, N M
通讯作者：
Probst-Hensch, N M
不同的基因与颗粒物质和烟草烟雾相互作用，在影响一般人群的肺功能下降时与烟雾烟相互作用。
影响因子：
3.7
作者：
Curjuric I;Imboden M;Nadif R;Kumar A;Schindler C;Haun M;Kronenberg F;Künzli N;Phuleria H;Postma DS;Russi EW;Rochat T;Demenais F;Probst-Hensch NM
通讯作者：
Probst-Hensch NM