Thiazolidinediones and Edema: Recent Advances in the Pathogenesis of Thiazolidinediones-Induced Renal Sodium Retention.
Thiazolidinediones and Edema: Recent Advances in the Pathogenesis of Thiazolidinediones-Induced Renal Sodium Retention.
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DOI：
10.1155/2015/646423
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发表时间：
2015
期刊：
影响因子：
2.9
通讯作者：
Seki G
中科院分区：
文献类型：
--
作者：
Horita S;Nakamura M;Satoh N;Suzuki M;Seki G
噻唑烷二酮类（TZDs）是一类应用广泛的抗糖尿病药物。TZD通过激活过氧化物酶体增殖物激活受体γ（PPARγ）改善胰岛素抵抗，并至少在实验动物中改善糖尿病和其他肾病。然而，TZDs有副作用，如水肿，充血性心力衰竭和骨折，并可能增加膀胱癌的风险。水肿和心力衰竭，这两个可能起源于肾钠潴留，是非常重要的，因为这些副作用使得很难继续使用TZD。然而，水肿的发病机制仍然存在争议。最初，TZD上调集合管中的上皮钠通道（ENaC）被认为是水肿的主要原因。然而，其他研究的结果并不支持这一观点。最近的数据表明，近端小管中的转运蛋白，如钠-碳酸氢盐协同转运蛋白和钠-质子交换剂的参与。其他研究表明，钠-钾-氯协同转运蛋白2在汉勒氏粗升支和水通道蛋白也可能是TZDs的目标。本文就TZD引起的肾小管钠重吸收和水肿的发病机制作一综述。
Thiazolidinediones (TZDs) are one of the major classes of antidiabetic drugs that are used widely. TZDs improve insulin resistance by activating peroxisome proliferator-activated receptor gamma (PPARγ) and ameliorate diabetic and other nephropathies, at least, in experimental animals. However, TZDs have side effects, such as edema, congestive heart failure, and bone fracture, and may increase bladder cancer risk. Edema and heart failure, which both probably originate from renal sodium retention, are of great importance because these side effects make it difficult to continue the use of TZDs. However, the pathogenesis of edema remains a matter of controversy. Initially, upregulation of the epithelial sodium channel (ENaC) in the collecting ducts by TZDs was thought to be the primary cause of edema. However, the results of other studies do not support this view. Recent data suggest the involvement of transporters in the proximal tubule, such as sodium-bicarbonate cotransporter and sodium-proton exchanger. Other studies have suggested that sodium-potassium-chloride cotransporter 2 in the thick ascending limb of Henle and aquaporins are also possible targets for TZDs. This paper will discuss the recent advances in the pathogenesis of TZD-induced sodium reabsorption in the renal tubules and edema.
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影响因子：
64.8
作者：
通讯作者：
--
影响因子：
64.8
作者：
Banks, Alexander S.;McAllister, Fiona E.;Camporez, Joao Paulo G.;Zushin, Peter-James H.;Jurczak, Michael J.;Laznik-Bogoslavski, Dina;Shulman, Gerald I.;Gygi, Steven P.;Spiegelman, Bruce M.
通讯作者：
Spiegelman, Bruce M.
影响因子：
82.9
作者：
通讯作者：
--
影响因子：
7.7
作者：
FUJITA, T;SUGIYAMA, Y;SUZUOKI, Z
通讯作者：
SUZUOKI, Z
影响因子：
168.9
作者：
Dormandy, JA;Charbonnel, B;Taton, J
通讯作者：
Taton, J