A marker of biological age explains individual variation in the strength of the adult stress response.
A marker of biological age explains individual variation in the strength of the adult stress response.
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DOI：
10.1098/rsos.171208
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发表时间：
2017-09
影响因子：
3.5
通讯作者：
Bateson M
中科院分区：
文献类型：
--
作者：
Andrews C;Nettle D;Larriva M;Gillespie R;Reichert S;Brilot BO;Bedford T;Monaghan P;Spencer KA;Bateson M
急性应激反应的功能是确定行为和生理过程的优先顺序，以便在面临直接威胁时最大限度地延长生存时间。成人应激反应的强度在个体之间存在差异，这是进化生物学和医学都感兴趣的问题。年龄是这种差异的一个确定的来源--在一系列物种中，压力反应随着年龄的增长而减少--但仍存在无法解释的差异。由于相同年龄的个体在生物衰老的速度上可能有明显的差异，我们询问生物年龄--这里通过红细胞端粒长度测量--是否可以预测相同年龄的成年动物的应激反应的变化。我们研究了两组欧洲八哥，之前我们通过实验改变雏鸟在孵化后两周内经历的竞争来操纵生物衰老的速度。我们预测，具有更大发育端粒磨损的个体，因此更大的生物年龄，在成年后进行测试时，会对急性应激源表现出减弱的皮质酮(CORT)反应。在这两个队列中，我们发现，在应激暴露后15到30 分钟内，具有更多发育端粒磨损的鸟类的皮质醇水平峰值更低，皮质酮水平变化更负面。因此，我们的结果提供了强有力的证据，表明生物年龄的衡量标准可以解释压力反应的个体差异：生物年龄较大的鸟类对压力的反应较弱。我们的结果为应激反应的发育程序化现象提供了一种新的解释：由于暴露在早年逆境中，观察到的应激生理学变化可能反映了衰老的变化。
The acute stress response functions to prioritize behavioural and physiological processes that maximize survival in the face of immediate threat. There is variation between individuals in the strength of the adult stress response that is of interest in both evolutionary biology and medicine. Age is an established source of this variation—stress responsiveness diminishes with increasing age in a range of species—but unexplained variation remains. Since individuals of the same chronological age may differ markedly in their pace of biological ageing, we asked whether biological age—measured here via erythrocyte telomere length—predicts variation in stress responsiveness in adult animals of the same chronological age. We studied two cohorts of European starlings in which we had previously manipulated the rate of biological ageing by experimentally altering the competition experienced by chicks in the fortnight following hatching. We predicted that individuals with greater developmental telomere attrition, and hence greater biological age, would show an attenuated corticosterone (CORT) response to an acute stressor when tested as adults. In both cohorts, we found that birds with greater developmental telomere attrition had lower peak CORT levels and a more negative change in CORT levels between 15 and 30 min following stress exposure. Our results, therefore, provide strong evidence that a measure of biological age explains individual variation in stress responsiveness: birds that were biologically older were less stress responsive. Our results provide a novel explanation for the phenomenon of developmental programming of the stress response: observed changes in stress physiology as a result of exposure to early-life adversity may reflect changes in ageing.
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影响因子：
2.5
作者：
Bloxham, Louise;Bateson, Melissa;Bedford, Thomas;Brilot, Ben;Nettle, Daniel
通讯作者：
Nettle, Daniel
影响因子：
5.2
作者：
Heidinger, Britt J.;Chastel, Olivier;Ketterson, Ellen D.
通讯作者：
Ketterson, Ellen D.
影响因子：
2.7
作者：
Heidinger, Britt J.;Nisbet, Ian C. T.;Ketterson, Ellen D.
通讯作者：
Ketterson, Ellen D.
影响因子：
3.5
作者：
Kriengwatana, B.;Wada, H.;MacDougall-Shackleton, S. A.
通讯作者：
MacDougall-Shackleton, S. A.
影响因子：
2.7
作者：
Lendvai, Adam Z.;Loiseau, Claire;Chastel, Olivier
通讯作者：
Chastel, Olivier