Coupling of replication and assembly in flaviviruses.

Coupling of replication and assembly in flaviviruses.
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DOI:
10.1016/j.coviro.2014.09.020
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发表时间:
2014-12
影响因子:
5.9
通讯作者:
Kuhn, Richard J.
Kuhn, Richard J.
中科院分区:
医学2区
文献类型:
--
作者:
Apte-Sengupta, Swapna;Sirohi, Devika;Kuhn, Richard J.

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Flaviviruses affect hundreds of millions of people each year causing tremendous morbidity and mortality worldwide. This genus includes significant human pathogens such as dengue, West Nile, yellow fever, tick-borne encephalitis and Japanese encephalitis virus among many others. The disease caused by these viruses can range from febrile illness to hemorrhagic fever and encephalitis. A deeper understanding of the virus life cycle is required to foster development of antivirals and vaccines, which are an urgent need for many flaviviruses, especially dengue. The focus of this review is to summarize our current knowledge of flaviviral replication and assembly, the proteins and lipids involved therein, and how these processes are coordinated for efficient virus production.
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