Thymic Stromal Lymphopoietin Induction Suppresses Lung Cancer Development.
Thymic Stromal Lymphopoietin Induction Suppresses Lung Cancer Development.
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作者：
肺癌切除原发肿瘤后复发率很高。在此，我们通过检查胸腺基质淋巴细胞生成素（TSLP）细胞因子诱导对早期肺癌发展的影响，证明了免疫疗法对抗肺癌的潜力。 TSLP 诱导可抑制自发性肺癌小鼠模型中侵袭性肺肿瘤的发展。这种癌症抑制依赖于 CD4+ T 细胞，这凸显了适应性免疫反应在防止肺癌进展中的作用。肺癌是美国和世界各地癌症死亡的主要原因。免疫疗法可激活肿瘤浸润的细胞毒性 T 淋巴细胞，已证明对治疗晚期肺癌有效。然而，利用免疫系统对抗肺癌早期阶段以预防癌症发展和复发的潜力仍有待探索。使用肺腺癌小鼠模型，我们研究了胸腺基质淋巴细胞生成素（TSLP）诱导对肺部早期癌症发展的影响。在此，我们证明全身 TSLP 诱导可抑制 KrasG12D 小鼠自发性肺癌的发展。 TSLP 驱动显着的 CD4+ T 细胞反应，阻止肺癌从非典型肺泡增生发展为腺癌。我们的研究结果表明，TSLP 可用于肺癌发展的早期阶段，以触发组织的持久免疫力并预防晚期疾病的发展。
The recurrence rate for lung cancer is high after the removal of the primary tumor. Herein, we demonstrate the potential of immunotherapy against lung cancer by examining the impact of Thymic Stromal Lymphopoietin (TSLP) cytokine induction on early lung cancer development. TSLP induction suppresses the development of invasive lung tumors in a mouse model of spontaneous lung cancer. This cancer suppression is dependent on CD4+ T cells, which highlights the role of adaptive immune response in protection against lung cancer progression. Lung cancer is the leading cause of cancer deaths in the United States and across the world. Immunotherapies, which activate tumor-infiltrating cytotoxic T lymphocytes, have demonstrated efficacy for the treatment of advanced-stage lung cancer. However, the potential for harnessing the immune system against the early stages of lung carcinogenesis to prevent cancer development and recurrence remains unexplored. Using a mouse model of lung adenocarcinoma, we investigated the effects of thymic stromal lymphopoietin (TSLP) induction on early cancer development in the lungs. Herein, we demonstrate that systemic TSLP induction suppressed spontaneous lung cancer development in KrasG12D mice. TSLP drove a significant CD4+ T cell response to block lung cancer progression from atypical alveolar hyperplasia to adenocarcinoma. Our findings suggest that TSLP can be used in the early stages of lung cancer development to trigger a lasting immunity in the tissue and prevent the development of advanced disease.
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DOI：
10.4049/jimmunol.1100463
发表时间：
2011-05-15
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Olkhanud PB;Rochman Y;Bodogai M;Malchinkhuu E;Wejksza K;Xu M;Gress RE;Hesdorffer C;Leonard WJ;Biragyn A
通讯作者：
Biragyn A
影响因子：
50.3
作者：
Demehri, Shadmehr;Turkoz, Ahu;Kopan, Raphael
通讯作者：
Kopan, Raphael
DOI：
10.1084/jem.20101876
发表时间：
2011-03-14
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
De Monte L;Reni M;Tassi E;Clavenna D;Papa I;Recalde H;Braga M;Di Carlo V;Doglioni C;Protti MP
通讯作者：
Protti MP
影响因子：
5.9
作者：
El-Zein, Mariam;Parent, Marie-Elise;Rousseau, Marie-Claude
通讯作者：
Rousseau, Marie-Claude
影响因子：
5.3
作者：
Gao, Ge;Liao, Weiting;Wang, Yongsheng
通讯作者：
Wang, Yongsheng