Unilateral superior laryngeal nerve lesion in an animal model of dysphagia and its effect on sucking and swallowing.
Unilateral superior laryngeal nerve lesion in an animal model of dysphagia and its effect on sucking and swallowing.
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DOI：
10.1007/s00455-013-9448-y
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发表时间：
2013-09
期刊：
影响因子：
2.6
通讯作者：
German, Rebecca Z.
中科院分区：
文献类型：
--
作者：
Ding, Peng;Campbell-Malone, Regina;Holman, Shaina D.;Lukasik, Stacey L.;Fukuhara, Takako;Gierbolini-Norat, Estela M.;Thexton, Allan J.;German, Rebecca Z.
关键词：
我们在婴儿动物模型中测试了与单侧上级喉神经（SLN）损伤后感觉缺陷相关的两个假设。我们假设这将导致（1）误吸发生率较高和（2）吸吮和吞咽的时间变化。我们结扎了6只2-3周龄的雌性猪的右侧SLN。使用视频荧光透视，我们记录了吞咽在相同的前和后病变的幼猪。我们分析了误吸的发生率以及吸吮和吞咽周期的持续时间和潜伏期。单侧SLN损伤后，吞咽时无声误吸的发生率从0.7%增加到41.5%。在病变后吞咽中，含吞咽的吸吮、吞咽后立即吸吮和吞咽本身的持续时间显著更长，尽管吞咽前的吸吮没有差异。在病变后吞咽中，含吞咽的吮吸开始与随后的会厌运动之间的间隔较长。与病变前吞咽相比，病变后吞咽之间的吮吸次数显著更大。单侧SLN损伤可增加误吸发生率，改变吮吸与吞咽的时间关系。较长的通过时间和吸吮和吞咽周期之间的时间协调功能障碍可能有助于误吸。这些结果表明，吞咽功能障碍和无声误吸是单侧SLN损伤的常见和潜在被忽视的后遗症。这种经验证的误吸动物模型有可能用于进一步的吞咽困难研究。
We tested two hypotheses relating to the sensory deficit that follows a unilateral superior laryngeal nerve (SLN) lesion in an infant animal model. We hypothesized that it would result in (1) a higher incidence of aspiration and (2) temporal changes in sucking and swallowing. We ligated the right-side SLN in six 2–3-week-old female pigs. Using videofluoroscopy, we recorded swallows in the same pre- and post-lesion infant pigs. We analyzed the incidence of aspiration and the duration and latency of suck and swallow cycles. After unilateral SLN lesioning, the incidence of silent aspiration during swallowing increased from 0.7 to 41.5 %. The durations of the suck containing the swallow, the suck immediately following the swallow, and the swallow itself were significantly longer in the post-lesion swallows, although the suck prior to the swallow was not different. The interval between the start of the suck containing a swallow and the subsequent epiglottal movement was longer in the post-lesion swallows. The number of sucks between swallows was significantly greater in post-lesion swallows compared to pre-lesion swallows. Unilateral SLN lesion increased the incidence of aspiration and changed the temporal relationships between sucking and swallowing. The longer transit time and the temporal coordinative dysfunction between suck and swallow cycles may contribute to aspiration. These results suggest that swallow dysfunction and silent aspiration are common and potentially overlooked sequelae of unilateral SLN injury. This validated animal model of aspiration has the potential for further dysphagia studies.
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