Highly biocompatible graphene quantum dots: green synthesis, toxicity comparison and fluorescence imaging
Highly biocompatible graphene quantum dots: green synthesis, toxicity comparison and fluorescence imaging
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高生物相容性石墨烯量子点：绿色合成、毒性比较和荧光成像
DOI：
10.1007/s10853-019-04079-2
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发表时间：
2020-01
影响因子：
4.5
通讯作者：
Wang Chaoli
中科院分区：
文献类型：
--
作者：
Yan Chaoren;Hu Xiaoling;Guan Ping;Hou Tongtong;Chen Peng;Wan Dewei;Zhang Xinli;Wang Jian;Wang Chaoli
石墨烯量子点（GQD）由于明亮的可见光发光任务而在生物成像中具有巨大的潜力。但是，繁琐的制备程序和GQD的潜在毒性极大地限制了它们在生物FI中的应用
Graphene quantum dots (GQDs) have tremendous potential in biological imaging due to their bright visible photoluminescence mission. However, the tedious preparation procedures and potential toxicity of GQDs greatly limit their application in biological field. Here, highly biocompatible GQDs (HGQDs) have been successfully prepared only by glucose in aqueous solution. Compared with GQDs prepared from conventional methods (CGQDs), the cytotoxicity of HGQDs reduced by more than 60%, and the flow cytometric analysis of the normal cells treated with HGQDs showed that the early and late apoptotic rate reduced by more than 72% and 40%, respectively. In vitro fluorescence imaging showed that both cells and bacteria could be imaged by HGQDs, and the morphology of cells and bacteria could be kept to a maximum extent. A long-term in vivo study revealed that no obvious organ (heart, liver, spleen, lung and kidney) damage or lesions were observed, and the blood–brain barrier (BBB) could be overcome, which provides the possibility for treatment and diagnosis of brain-related diseases. With adequate studies of biocompatibility, both in vitro and in vivo, HGQDs may be considered for further biological application.
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影响因子：
10
作者：
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影响因子：
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影响因子：
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作者：
Li, Qiqi;Zhang, Sheng;Li, Liang-shi
通讯作者：
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