Glycaemic control boosts glucosylated nanocarrier crossing the BBB into the brain.
Glycaemic control boosts glucosylated nanocarrier crossing the BBB into the brain.
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DOI：
10.1038/s41467-017-00952-3
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发表时间：
2017-10-17
影响因子：
16.6
通讯作者：
Kataoka K
中科院分区：
文献类型：
--
作者：
Anraku Y;Kuwahara H;Fukusato Y;Mizoguchi A;Ishii T;Nitta K;Matsumoto Y;Toh K;Miyata K;Uchida S;Nishina K;Osada K;Itaka K;Nishiyama N;Mizusawa H;Yamasoba T;Yokota T;Kataoka K
近年来，将生物活性物质转运到体内靶点的纳米载体引起了广泛的关注，并在技术水平方面经历了快速的发展。然而，很少有纳米载体能够通过血脑屏障（BBB）经由全身途径进入大脑以有效地到达神经元。在这里，我们制备了一种自组装的超分子纳米载体，其表面具有适当配置的葡萄糖。这种纳米载体的BBB穿越和脑蓄积通过禁食后的快速血流量增加以及脑毛细血管内皮细胞中高表达葡萄糖转运蛋白-1（GLUT 1）从管腔质膜迁移到近腔质膜的推定现象而得到促进。纳米载体表面上精确控制的葡萄糖密度能够调节其在脑内的分布，从而成功地优化以增加在神经元中积累的纳米载体的数量。只有少数几个纳米载体可以运输生物活性物质穿过血脑屏障。在这里，作者表明，通过快速增加血糖，可以控制葡萄糖基化纳米载体在大脑中的积累。
Recently, nanocarriers that transport bioactive substances to a target site in the body have attracted considerable attention and undergone rapid progression in terms of the state of the art. However, few nanocarriers can enter the brain via a systemic route through the blood-brain barrier (BBB) to efficiently reach neurons. Here we prepare a self-assembled supramolecular nanocarrier with a surface featuring properly configured glucose. The BBB crossing and brain accumulation of this nanocarrier are boosted by the rapid glycaemic increase after fasting and by the putative phenomenon of the highly expressed glucose transporter-1 (GLUT1) in brain capillary endothelial cells migrating from the luminal to the abluminal plasma membrane. The precisely controlled glucose density on the surface of the nanocarrier enables the regulation of its distribution within the brain, and thus is successfully optimized to increase the number of nanocarriers accumulating in neurons. There are only a few examples of nanocarriers that can transport bioactive substances across the blood-brain barrier. Here the authors show that by rapid glycaemic increase the accumulation of a glucosylated nanocarrier in the brain can be controlled.
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影响因子：
38.3
作者：
Geng, Yan;Dalhaimer, Paul;Discher, Dennis E.
通讯作者：
Discher, Dennis E.
影响因子：
3.6
作者：
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影响因子：
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通讯作者：
Matsumura, Y
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影响因子：
14
作者：
Jiang, Xinyi;Xin, Hongliang;Fang, Xiaoling
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Fang, Xiaoling
影响因子：
3.4
作者：
Matsumoto, Yu;Nomoto, Takahiro;Kataoka, Kazunori
通讯作者：
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