Osteocalcin, Vascular Calcification, and Atherosclerosis: A Systematic Review and Meta-analysis.
Osteocalcin, Vascular Calcification, and Atherosclerosis: A Systematic Review and Meta-analysis.
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DOI：
10.3389/fendo.2017.00183
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发表时间：
2017
影响因子：
5.2
通讯作者：
O'Sullivan SE
中科院分区：
文献类型：
--
作者：
Millar SA;Patel H;Anderson SI;England TJ;O'Sullivan SE
骨钙素（Osteocalcin，OC）是一种非常有趣的激素，同时也是骨矿化基质中含量最丰富的非胶原肽，具有广泛的骨外效应，能增强骨骼的内分泌功能。OC和血管钙化之间出现了一个新的调查线，以响应观察到血管钙化的机制类似于骨矿化。迄今为止，研究报告的结果喜忧参半。本系统综述和荟萃分析旨在确定OC与血管钙化和动脉粥样硬化之间的任何关联。检索数据库中的原始、同行评议的人体研究。共检索到1，453篇文章，其中46篇符合合格标准。总体而言，OC（血液中的浓度、OC阳性细胞的存在或OC的组织学染色）与钙化或动脉粥样硬化程度之间的评估报告了26个阳性、17个阴性和29个中性关系。测量OC阳性细胞或OC组织学染色的研究报告了阳性关系（11项研究）。与欧洲研究（6%）相比，亚洲研究（36%）发现了更高比例的负面关系。检查血液中羧基化和羧基化不足形式的OC的研究未能报告一致的结果。荟萃分析发现“动脉粥样硬化”患者和对照组之间的血液OC浓度无显著差异（p = 0.13，n = 1，197）。OC和血管钙化或动脉粥样硬化之间没有明确的联系，但是，OC阳性细胞和组织学染色的存在与钙化或动脉粥样硬化有一致的正相关性。该评论强调了几个主题，这些主题可能会影响不同人群中的OC，导致不确定的结果。需要进行大规模的纵向研究，以进一步了解OC在血管钙化和动脉粥样硬化中的临床意义。
Osteocalcin (OC) is an intriguing hormone, concomitantly being the most abundant non-collagenous peptide found in the mineralized matrix of bone, and expanding the endocrine function of the skeleton with far-reaching extra-osseous effects. A new line of enquiry between OC and vascular calcification has emerged in response to observations that the mechanism of vascular calcification resembles that of bone mineralisation. To date, studies have reported mixed results. This systematic review and meta-analysis aimed to identify any association between OC and vascular calcification and atherosclerosis. Databases were searched for original, peer reviewed human studies. A total of 1,453 articles were retrieved, of which 46 met the eligibility criteria. Overall 26 positive, 17 negative, and 29 neutral relationships were reported for assessments between OC (either concentration in blood, presence of OC-positive cells, or histological staining for OC) and extent of calcification or atherosclerosis. Studies that measured OC-positive cells or histological staining for OC reported positive relationships (11 studies). A higher percentage of Asian studies found a negative relationship (36%) in contrast to European studies (6%). Studies examining carboxylated and undercarboxylated forms of OC in the blood failed to report consistent results. The meta-analysis found no significant difference between OC concentration in the blood between patients with “atherosclerosis” and control (p = 0.13, n = 1,197). No definitive association was determined between OC and vascular calcification or atherosclerosis; however, the presence of OC-positive cells and histological staining had a consistent positive correlation with calcification or atherosclerosis. The review highlighted several themes, which may influence OC within differing populations leading to inconclusive results. Large, longitudinal studies are required to further current understanding of the clinical relevance of OC in vascular calcification and atherosclerosis.
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