Differential B7-CD28 costimulatory requirements for stable and inflationary mouse cytomegalovirus-specific memory CD8 T cell populations.
Differential B7-CD28 costimulatory requirements for stable and inflationary mouse cytomegalovirus-specific memory CD8 T cell populations.
复制标题
DOI：
10.4049/jimmunol.1003231
复制
发表时间：
2011-04-01
期刊：
影响因子：
--
通讯作者：
Schoenberger SP
中科院分区：
文献类型：
--
作者：
Arens R;Loewendorf A;Redeker A;Sierro S;Boon L;Klenerman P;Benedict CA;Schoenberger SP
Cytomegalovirus (CMV) establishes a lifelong persistent infection, and viral immune modulating strategies are important to facilitate this. A particularly diverse CD8 T cell response develops as a result of this host-virus détente, with the CMV-specific memory T cell pool displaying unique functions and phenotypes. To gain insight into the factors that regulate CMV-specific CD8 T cell responses, we examined the influence of the B7-CD28 costimulatory pathway on the magnitude, kinetics and phenotype. Initial expansion of mouse CMV-specific CD8 T cells that establish stable memory pools was severely lower in mice lacking B7-CD28 signaling, and the resulting memory levels also remaining reduced during persistent/latent infection. In contrast, expansion of CD8 T cells that undergo memory inflation during chronic infection was less impacted in the absence of B7-CD28 costimulatory signals, eventually reaching the levels seen in wild-type mice at later times. Regardless of their differential requirements for B7-CD28 signals, both stable and inflationary memory T cell populations showed normal cytotoxic capacity. These results reveal that B7-CD28 costimulation differentially regulates the magnitude and kinetics of the multifaceted CD8 T cell response that develops during CMV infection.
登录
查看更多内容
影响因子：
5.4
作者：
Liu, Jie;Ruckwardt, Tracy J.;Graham, Barney S.
通讯作者：
Graham, Barney S.
DOI：
10.1186/1742-4933-3-11
发表时间：
2006-12-08
期刊：
Immunity & ageing : I & A
影响因子：
--
作者：
Komatsu, Haruki;Inui, Ayano;Klenerman, Paul
通讯作者：
Klenerman, Paul
影响因子：
5.4
作者：
Karrer, U;Wagner, M;Klenerman, P
通讯作者：
Klenerman, P
影响因子：
5.4
作者：
Simon, Christian O.;Holtappels, Rafaela;Grzimek, Natascha K. A.
通讯作者：
Grzimek, Natascha K. A.
影响因子：
32.4
作者：
Snyder, Christopher M.;Cho, Kathy S.;Bonnett, Elizabeth L.;van Dommelen, Serani;Shellam, Geoffrey R.;Hill, Ann B.
通讯作者：
Hill, Ann B.