Memory inflation during chronic viral infection is maintained by continuous production of short-lived, functional T cells.
Memory inflation during chronic viral infection is maintained by continuous production of short-lived, functional T cells.
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DOI：
10.1016/j.immuni.2008.07.017
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发表时间：
2008-10-17
期刊：
影响因子：
32.4
通讯作者：
Hill, Ann B.
中科院分区：
文献类型：
--
作者：
Snyder, Christopher M.;Cho, Kathy S.;Bonnett, Elizabeth L.;van Dommelen, Serani;Shellam, Geoffrey R.;Hill, Ann B.
在持续性鼠巨细胞病毒（MCMV）感染期间，T细胞应答在宿主的生命中维持在极高水平。这些细胞非常类似于人CMV特异性细胞，其构成大多数人外周T细胞区室的主要成分。尽管表型表明广泛的抗原驱动的分化，MCMV特异性T细胞保持功能，并积极响应病毒的挑战。我们假设，抗原驱动的增殖率较低，这可能是维持这一群体的原因。相反，我们发现这些细胞中的大多数在慢性感染的宿主中仅零星分裂，并且在循环中的半衰期很短。总的群体至少部分地受到在感染早期引发的记忆细胞以及在晚期募集幼稚T细胞的支持。这些数据表明，在慢性MCMV感染期间，记忆膨胀是通过持续更换短寿命的功能性细胞来维持的。
During persistent murine cytomegalovirus (MCMV) infection the T cell response is maintained at extremely high levels for the life of the host. These cells closely resemble human CMV-specific cells which comprise a major component of the peripheral T cell compartment in most people. Despite a phenotype that suggests extensive antigen-driven differentiation, MCMV-specific T cells remain functional and respond vigorously to viral challenge. We hypothesized that a low rate of antigen-driven proliferation would account for the maintenance of this population. Instead, we found that most of these cells divide only sporadically in chronically infected hosts and have a short half-life in circulation. The overall population is supported, at least in part, by memory cells primed early in infection as well as recruitment of naïve T cells at late times. These data show that memory inflation is maintained by a continuous replacement of short-lived, functional cells during chronic MCMV infection.
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DOI：
10.1084/jem.20052237
发表时间：
2006-04-17
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Jabbari A;Harty JT
通讯作者：
Harty JT
激活表型，而不是中心或效应子内存表型，可预测记忆CD8+ T细胞的回忆功效。
影响因子：
15.3
作者：
Hikono, Hirokazu;Kohlmeier, Jacob E.;Takamura, Shiki;Wittmer, Susan T.;Roberts, Alan D.;Woodland, David L.
通讯作者：
Woodland, David L.
影响因子：
5.4
作者：
Karrer, U;Wagner, M;Klenerman, P
通讯作者：
Klenerman, P
影响因子：
4.4
作者：
Masopust, David;Ha, Sang-Jun;Ahmed, Rafi
通讯作者：
Ahmed, Rafi
通过HLA肽四聚体选择后，巨细胞病毒特异性CTL转移给干细胞移植患者。
影响因子：
15.3
作者：
Cobbold, M;Khan, N;Pourgheysari, B;Tauro, S;McDonald, D;Osman, H;Assenmacher, M;Billingham, L;Steward, C;Crawley, C;Olavarria, E;Goldman, J;Chakraverty, R;Mahendra, P;Craddock, C;Moss, PAH
通讯作者：
Moss, PAH