L-selenomethionine does not protect against testosterone plus 17β-estradiol-induced oxidative stress and preneoplastic lesions in the prostate of NBL rats.
L-selenomethionine does not protect against testosterone plus 17β-estradiol-induced oxidative stress and preneoplastic lesions in the prostate of NBL rats.
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DOI：
10.1080/01635581.2014.904907
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发表时间：
2014
期刊：
影响因子：
--
通讯作者：
Bosland MC
中科院分区：
文献类型：
--
作者：
Özten N;Schlicht M;Diamond AM;Bosland MC
Previous animal studies examining dietary selenium effects on prostatic carcinogenesis did not show preventive benefit, including one study in a rat model involving testosterone (T) and estradiol (E2)-induced prostatic oxidative stress. Here, we examined modulation of T+E2-induced prostatic oxidative stress, dysplasia, and inflammation by L-selenomethionine at 1.5 or 3.0 mg selenium/kg in NIH-07 diet in Nbl/Crl rats treated with T+E2 for 16 weeks. Hormone treatment increased immunohistochemical staining for 8-hydroxydeoxyguanosine (8-OHdG) in the prostatic sites of T+E2-induced preneoplasia (p<0.05), but selenomethionine did not attenuate 8-OHdG staining and dysplasia in the lateral prostate. Glutathione-peroxidase activity and mRNA expression were induced by T+E2 (p<0.05–p<0.0001) but not changed by selenomethionine. Selenomethionine did not cause significant responses in expression and activity of glutathione-peroxidase and MnSOD, except for a reduction of MnSOD protein expression in the lateral prostate (p<0.01). The absence of reduction of oxidative stress and dysplasia and the minimal effects on antioxidant enzymes caused by selenomethionine are consistent with the null effects observed in selenium supplementation animal studies and clinical trials. Significant (p<0.01) opposite apoptosis/cell proliferation balance responses to selenomethionine and to T+E2 occurred in the lateral and dorsal prostate, explaining why T+E2 induces lesions selectively in the lateral lobe of NBL rats.
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影响因子：
4.7
作者：
BOSLAND, MC;FORD, H;HORTON, L
通讯作者：
HORTON, L
影响因子：
7.8
作者：
Borrás, C;Gambini, J;Viña, J
通讯作者：
Viña, J
影响因子：
9.7
作者：
HO, SM;ROY, D
通讯作者：
ROY, D
DOI：
10.1158/1940-6207.capr-09-0176
发表时间：
2010-03
期刊：
Cancer prevention research (Philadelphia, Pa.)
影响因子：
--
作者：
McCormick DL;Rao KV;Johnson WD;Bosland MC;Lubet RA;Steele VE
通讯作者：
Steele VE
DOI：
10.1097/mco.0b013e3283139674
发表时间：
2008-11-01
影响因子：
3.1
作者：
Jackson, Matthew I.;Combs, Gerald F., Jr.
通讯作者：
Combs, Gerald F., Jr.