Long term stability of nanowire nanoelectronics in physiological environments.
Long term stability of nanowire nanoelectronics in physiological environments.
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DOI：
10.1021/nl500070h
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发表时间：
2014-03-12
期刊：
影响因子：
10.8
通讯作者：
Lieber CM
中科院分区：
文献类型：
--
作者：
Zhou W;Dai X;Fu TM;Xie C;Liu J;Lieber CM
纳米线纳米电子器件已被开发为高灵敏度的亚细胞分辨率检测器，用于记录细胞外和细胞内信号，以及从自然和工程/半机械组织，并在此能力打开许多机会，基础生物学研究和生物医学应用。在这里，我们展示了充分利用纳米线纳米电子器件的吸引力的能力，长期的生理研究，通过钝化的纳米线元素与金属氧化物壳的能力。Si和Si/氧化铝（Al 2 O3）核/壳纳米线在37 °C下在生理溶液中的研究表明，在涂覆有10 nm厚的Al 2 O3壳的样品中，长期稳定性延长至少100天。此外，对配置为场效应晶体管（FET）的纳米线的研究表明，Si/Al 2 O3核/壳纳米线FET在37 °C的生理模型溶液中表现出至少4个月的良好器件性能。该方法的通用性也在Ge/Si和InAs纳米线的研究中进行了测试，其中Ge/Si/Al 2 O3和InAs/Al 2 O3核/壳材料在37 °C的生理模型溶液中表现出至少100天的稳定性。此外，氧化铪-Al 2 O3纳米层压壳的研究表明，在体内将纳米线的稳定性延长到1年以上的潜力。这些研究表明，简单的核/壳纳米线纳米电子器件可以表现出一系列动物慢性体内研究所需的长期稳定性，以及可以改善疾病监测和治疗的强大生物医学植入物。
Nanowire nanoelectronic devices have been exploited as highly sensitive subcellular resolution detectors for recording extracellular and intracellular signals from cells, as well as from natural and engineered/cyborg tissues, and in this capacity open many opportunities for fundamental biological research and biomedical applications. Here we demonstrate the capability to take full advantage of the attractive capabilities of nanowire nanoelectronic devices for long term physiological studies by passivating the nanowire elements with ultrathin metal oxide shells. Studies of Si and Si/aluminum oxide (Al2O3) core/shell nanowires in physiological solutions at 37 °C demonstrate long-term stability extending for at least 100 days in samples coated with 10 nm thick Al2O3 shells. In addition, investigations of nanowires configured as field-effect transistors (FETs) demonstrate that the Si/Al2O3 core/shell nanowire FETs exhibit good device performance for at least 4 months in physiological model solutions at 37 °C. The generality of this approach was also tested with in studies of Ge/Si and InAs nanowires, where Ge/Si/Al2O3 and InAs/Al2O3 core/shell materials exhibited stability for at least 100 days in physiological model solutions at 37 °C. In addition, investigations of hafnium oxide-Al2O3 nanolaminated shells indicate the potential to extend nanowire stability well beyond 1 year time scale in vivo. These studies demonstrate that straightforward core/shell nanowire nanoelectronic devices can exhibit the long term stability needed for a range of chronic in vivo studies in animals as well as powerful biomedical implants that could improve monitoring and treatment of disease.
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影响因子：
38.3
作者：
通讯作者：
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影响因子：
8.6
作者：
Groner, MD;Fabreguette, FH;George, SM
通讯作者：
George, SM
影响因子：
5
作者：
RIMSTIDT, JD;BARNES, HL
通讯作者：
BARNES, HL
影响因子：
14.8
作者：
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通讯作者：
Lieber, Charles M.
影响因子：
7.4
作者：
Patolsky, Fernando;Zheng, Gengfeng;Lieber, Charles M.
通讯作者：
Lieber, Charles M.