Remodeling of Bone Marrow Niches and Roles of Exosomes in Leukemia.
Remodeling of Bone Marrow Niches and Roles of Exosomes in Leukemia.
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DOI：
10.3390/ijms22041881
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发表时间：
2021-02-13
影响因子：
5.6
通讯作者：
Shimaoka M
中科院分区：
文献类型：
--
作者：
Yamaguchi T;Kawamoto E;Gaowa A;Park EJ;Shimaoka M
白血病是一种血液系统恶性肿瘤，起源于骨髓中的造血干细胞。在了解其发病机制以及建立化疗和造血干细胞移植疗法(HSCT)方面取得了重大进展。然而，尽管分子靶向治疗和免疫治疗等新疗法的相继发展取得了显著进展，但事实仍然是一些患者仍然无法挽救，耐药和复发仍然是白血病患者需要解决的问题。骨髓(BM)生态位是包括造血干细胞及其支持细胞的微环境。白血病细胞与骨髓壁龛相互作用并对其进行调节，不仅引起分子和功能的变化，而且还会切换到白血病细胞青睐的壁龛。后者与白血病进展、正常造血抑制和化疗耐药密切相关，而化疗耐药正是正在进行的研究领域。由于胞外体通过体液循环的性质，胞外体在细胞间的交流中扮演着重要的角色，不仅与近距离的细胞沟通，也与较远的细胞沟通。在白血病中，外切体在白血病的发生、疾病进展和器官侵袭中发挥着重要作用，近年来有报道称其在白血病的诊断和治疗中具有重要作用。白血病细胞来源的外切体与骨髓微环境之间的相互作用受到了特别的关注。它们的相互作用被认为发挥了非常重要的作用；除了它们的诊断价值外，外切体还可以作为监测治疗效果的标志和帮助克服耐药性，这是白血病患者尚未克服的许多问题之一。在这篇文章中，我们将回顾白血病的骨髓生态位，白血病来源的外切体的发现，以及外切体引起的骨髓生态位的变化。
Leukemia is a hematological malignancy that originates from hematopoietic stem cells in the bone marrow. Significant progress has made in understanding its pathogensis and in establishing chemotherapy and hematopoietic stem cell transplantation therapy (HSCT). However, while the successive development of new therapies, such as molecular-targeted therapy and immunotherapy, have resulted in remarkable advances, the fact remains that some patients still cannot be saved, and resistance to treatment and relapse are still problems that need to be solved in leukemia patients. The bone marrow (BM) niche is a microenvironment that includes hematopoietic stem cells and their supporting cells. Leukemia cells interact with bone marrow niches and modulate them, not only inducing molecular and functional changes but also switching to niches favored by leukemia cells. The latter are closely associated with leukemia progression, suppression of normal hematopoiesis, and chemotherapy resistance, which is precisely the area of ongoing study. Exosomes play an important role in cell-to-cell communication, not only with cells in close proximity but also with those more distant due to the nature of exosomal circulation via body fluids. In leukemia, exosomes play important roles in leukemogenesis, disease progression, and organ invasion, and their usefulness in the diagnosis and treatment of leukemia has recently been reported. The interaction between leukemia cell-derived exosomes and the BM microenvironment has received particular attention. Their interaction is believed to play a very important role; in addition to their diagnostic value, exosomes could serve as a marker for monitoring treatment efficacy and as an aid in overcoming drug resistance, among the many problems in leukemia patients that have yet to be overcome. In this paper, we will review bone marrow niches in leukemia, findings on leukemia-derived exosomes, and exosome-induced changes in bone marrow niches.
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影响因子：
12.8
作者：
Cortes J;Rea D;Lipton JH
通讯作者：
Lipton JH
影响因子：
21.3
作者：
Asada N;Kunisaki Y;Pierce H;Wang Z;Fernandez NF;Birbrair A;Ma'ayan A;Frenette PS
通讯作者：
Frenette PS
影响因子：
23.9
作者：
Duarte D;Hawkins ED;Akinduro O;Ang H;De Filippo K;Kong IY;Haltalli M;Ruivo N;Straszkowski L;Vervoort SJ;McLean C;Weber TS;Khorshed R;Pirillo C;Wei A;Ramasamy SK;Kusumbe AP;Duffy K;Adams RH;Purton LE;Carlin LM;Lo Celso C
通讯作者：
Lo Celso C
DOI：
10.1084/jem.20140131
发表时间：
2014-09-22
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Boyd AL;Campbell CJ;Hopkins CI;Fiebig-Comyn A;Russell J;Ulemek J;Foley R;Leber B;Xenocostas A;Collins TJ;Bhatia M
通讯作者：
Bhatia M
影响因子：
23.9
作者：
Hanoun, Maher;Zhang, Dachuan;Mizoguchi, Toshihide;Pinho, Sandra;Pierce, Halley;Kunisaki, Yuya;Lacombe, Julie;Armstrong, Scott A.;Duehrsen, Ulrich;Frenette, Paul S.
通讯作者：
Frenette, Paul S.