Development and regeneration of the inner ear.
Development and regeneration of the inner ear.
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DOI：
10.1111/j.1749-6632.2009.04484.x
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发表时间：
2009-07
影响因子：
5.2
通讯作者：
Segil N
中科院分区：
文献类型：
--
作者：
Kwan T;White PM;Segil N
感觉毛细胞的丧失是人类耳聋的主要原因。哺乳动物的耳蜗不能再生它的感觉毛细胞。因此，目前，唯一的治疗耳聋由于感觉毛细胞的损失是使用假肢，如助听器和人工耳蜗植入。相反，在非哺乳动物脊椎动物中，如鸟类，毛细胞再生发生在毛细胞死亡后，并导致听力的恢复。鸟类的再生是成功的，因为毛细胞周围的支持细胞可以分裂，并能够随后分化成新的毛细胞。然而，哺乳动物的支持细胞在毛细胞丢失时通常不会分裂或反分化，因此不会发生再生。为了理解哺乳动物耳蜗毛细胞再生的失败，我们需要了解在胚胎发生和出生后小鼠中细胞分裂控制和毛细胞分化的分子机制。在这篇综述中，我们介绍了胚胎发生和出生后成熟过程中细胞增殖的调控。我们还讨论了Cip/Kip细胞周期抑制剂和Notch信号在控制早期产后支持细胞分化状态稳定性中的作用。最后，最近的数据表明，一些早期出生后哺乳动物的支持细胞保留了分裂和转分化为感觉毛细胞的潜在能力。在一起,这些观察结果支持细胞重要的治疗目标继续努力,诱导头发细胞再生。
Loss of sensory hair cells is the leading cause of deafness in humans. The mammalian cochlea cannot regenerate its complement of sensory hair cells. Thus at present, the only treatment for deafness due to sensory hair cell loss is the use of prosthetics, such as hearing aids and cochlear implants. In contrast, in nonmammalian vertebrates, such as birds, hair cell regeneration occurs following the death of hair cells and leads to the restoration of hearing. Regeneration in birds is successful because supporting cells that surround the hair cells can divide and are able to subsequently differentiate into new hair cells. However, supporting cells in mammals do not normally divide or trans-differentiate when hair cells are lost, and so regeneration does not occur. To understand the failure of mammalian cochlear hair cell regeneration, we need to understand the molecular mechanisms that underlie cell division control and hair cell differentiation, both during embryogenesis and in the postnatal mouse. In this review, we present a discussion of the regulation of cell proliferation in embryogenesis and during postnatal maturation. We also discuss the role of the Cip/Kip cell cycle inhibitors and Notch signaling in the control of stability of the differentiated state of early postnatal supporting cells. Finally, recent data indicate that some early postnatal mammalian supporting cells retain a latent capacity to divide and transdifferentiate into sensory hair cells. Together, these observations make supporting cells important therapeutic targets for continued efforts to induce hair cell regeneration.
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DOI：
10.1111/j.1749-6632.1996.tb15693.x
发表时间：
1996-01-01
期刊：
NEW DIRECTIONS IN VESTIBULAR RESEARCH
影响因子：
--
作者：
Baird, RA;Steyger, PS;Schuff, NR
通讯作者：
Schuff, NR
影响因子：
2.5
作者：
Cafaro, Jon;Lee, Gi Soo;Stone, Jennifer S.
通讯作者：
Stone, Jennifer S.
DOI：
10.1111/j.1439-0485.2006.00089.x
发表时间：
2006-06-01
影响因子：
1.1
作者：
Lee, Sang Yong;Kim, Jeong Bae;Lee, Sung Mi
通讯作者：
Lee, Sung Mi
影响因子：
2.8
作者：
Janas, JD;Cotanche, DA;Rubel, EW
通讯作者：
Rubel, EW
影响因子：
4.5
作者：
Kiernan AE;Xu J;Gridley T
通讯作者：
Gridley T