Aspergillus niger as a Secondary Metabolite Factory.

Aspergillus niger as a Secondary Metabolite Factory.
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DOI:
10.3389/fchem.2021.701022
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发表时间:
2021
影响因子:
5.5
通讯作者:
Zhang H
Zhang H
中科院分区:
化学3区
文献类型:
--
作者:
Yu R;Liu J;Wang Y;Wang H;Zhang H

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黑曲霉是最常见和最重要的真菌物种之一,在各种环境中普遍存在。黑曲霉分离株拥有大量隐性生物合成基因簇(BGC),可产生多种生物分子作为次生代谢产物,应用领域广泛,涵盖农业、食品和制药工业。通过广泛的文献检索,本文对黑曲霉菌株的生物学和化学方面进行了全面的总结,包括其来源、BGC、次级代谢产物以及生物学特性和生物合成途径。本综述还提供了发现更多源自黑曲霉的功能性生物分子的未来前景。
Aspergillus niger, one of the most common and important fungal species, is ubiquitous in various environments. A. niger isolates possess a large number of cryptic biosynthetic gene clusters (BGCs) and produce various biomolecules as secondary metabolites with a broad spectrum of application fields covering agriculture, food, and pharmaceutical industry. By extensive literature search, this review with a comprehensive summary on biological and chemical aspects of A. niger strains including their sources, BGCs, and secondary metabolites as well as biological properties and biosynthetic pathways is presented. Future perspectives on the discovery of more A. niger-derived functional biomolecules are also provided in this review.
DOI: 10.1111/j.1365-3059.1994.tb01591.x
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