Investigation of functional connectivity in Bell's palsy using functional magnetic resonance imaging: prospective cross-sectional study.
Investigation of functional connectivity in Bell's palsy using functional magnetic resonance imaging: prospective cross-sectional study.
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DOI：
10.21037/qims-22-911
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发表时间：
2023-07-01
影响因子：
2.8
通讯作者：
中科院分区：
文献类型：
--
作者：
下运动神经元面瘫最常见的原因是贝尔氏麻痹（BP）。血压会导致受影响一侧的面部肌肉部分或完全无法自动移动，在某些情况下，甚至无法闭合眼睑，这可能会导致永久性眼睛损伤。这项研究调查了 BP 患者大脑功能和连接异常的变化。这项研究包括 46 名单侧血压患者和 34 名健康对照者 (HC)。获取了所有参与者的静息态脑功能磁共振成像（fMRI）图像，并获得了多伦多面部分级系统（TFGS）评分。估计低频波动的分数幅度 (fALFF)，并使用 BP 与 HC 患者中 fALFF 变化的大脑区域的相关性分析来确定 TFGS 和 fALFF 之间的关系。与 TFGS 相关的大脑区域被用作进一步功能连接（FC）分析的种子；还分析了异常区域的FC值与TFGS评分之间的关系。 BP组的右侧楔前叶、右侧角回、左侧边缘上回和左侧枕中回的激活显着降低。 BP组右侧丘脑、蚓部、小脑fALFF显着高于HC组（P<0.05）。左侧枕中回与右侧角回、左侧楔前叶、右侧额中回之间的FC急剧增加，而左侧角回、左侧后扣带回、左侧额中回、小脑下、左侧颞中回的FC降低。此外，左侧枕中回fALFF与TFGS评分呈负相关（R=0.144；P=0.008）。 BP的发病机制与大脑皮层的功能重组密切相关。 BP 患者与面部运动反馈监测相关的皮质区域的 fALFF 活动发生了改变。
The most common cause of lower motor neuron facial palsy is Bell’s palsy (BP). BP results in partial or complete inability to automatically move the facial muscles on the affected side and, in some cases, to close the eyelids, which can cause permanent eye damage. This study investigated changes in brain function and connectivity abnormalities in patients with BP. This study included 46 patients with unilateral BP and 34 healthy controls (HCs). Resting-state brain functional magnetic resonance imaging (fMRI) images were acquired, and Toronto Facial Grading System (TFGS) scores were obtained for all participants. The fractional amplitude of low-frequency fluctuation (fALFF) was estimated, and the relationship between the TFGS and fALFF was determined using correlation analysis for brain regions with changes in fALFF in those with BP versus HCs. Brain regions associated with TFGS were used as seeds for further functional connectivity (FC) analysis; relationships between FC values of abnormal areas and TFGS scores were also analyzed. Activation of the right precuneus, right angular gyrus, left supramarginal gyrus, and left middle occipital gyrus was significantly decreased in the BP group. fALFF was significantly higher in the right thalamus, vermis, and cerebellum of the BP group compared with that in the HC group (P<0.05). The FC between the left middle occipital gyrus and right angular gyrus, left precuneus, and right middle frontal gyrus increased sharply, but decreased in the left angular gyrus, left posterior cingulate gyrus, left middle frontal gyrus, inferior cerebellum, and left middle temporal gyrus. Furthermore, the fALFF in the left middle occipital gyrus was negatively correlated with TFGS score (R=0.144; P=0.008). The pathogenesis of BP is closely related to functional reorganization of the cerebral cortex. Patients with BP have altered fALFF activity in cortical regions associated with facial motion feedback monitoring.
影响因子：
4.3
作者：
Han X;Li H;Wang X;Zhu Y;Song T;Du L;Sun S;Guo R;Liu J;Shi S;Fu C;Gao W;Zhang L;Ma G
通讯作者：
Ma G