Periostin expression and epithelial-mesenchymal transition in cancer: a review and an update.
Periostin expression and epithelial-mesenchymal transition in cancer: a review and an update.
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DOI：
10.1007/s00428-011-1151-5
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发表时间：
2011-11
期刊：
影响因子：
3.5
通讯作者：
Moch, Holger
中科院分区：
文献类型：
--
作者：
Morra, Laura;Moch, Holger
Periostin，又称成骨细胞特异性因子2，是一种分泌的细胞粘附蛋白，与昆虫细胞粘附分子fasciclin i具有同源性，已被证明是骨和牙齿形成和维持以及心脏发育和愈合的重要调节因子。最近的研究表明，骨膜蛋白在肿瘤的发展中起着重要作用，在多种癌症中，如结肠癌、胰腺癌、卵巢癌、乳腺癌、头颈癌、甲状腺癌、胃癌以及神经母细胞瘤中都有上调。与整合素结合的Periostin激活Akt/PKB-和fak -介导的信号通路，从而增加癌细胞的存活、血管生成、侵袭、转移，以及重要的上皮-间质转化。在这篇综述中，我们总结了最近关于骨膜蛋白在肺癌、肾癌、前列腺癌、肝癌和恶性胸膜间皮瘤中的表达的临床病理研究，并讨论了骨膜蛋白异构体在肿瘤发生中的作用及其作为基质靶向抗癌治疗靶点的潜力。
Periostin, also called osteoblast-specific factor 2, is a secreted cell adhesion protein, which shares a homology with the insect cell adhesion molecule fasciclin I. It has been shown to be an important regulator of bone and tooth formation and maintenance, and of cardiac development and healing. Recent studies revealed that periostin plays an important role in tumor development and is upregulated in a wide variety of cancers such as colon, pancreatic, ovarian, breast, head and neck, thyroid, and gastric cancer as well as in neuroblastoma. Periostin binding to the integrins activates the Akt/PKB- and FAK-mediated signaling pathways which lead to increased cell survival, angiogenesis, invasion, metastasis, and importantly, epithelial-mesenchymal transition of carcinoma cells. In this review we summarize recent clinicopathological studies that have investigated periostin expression in lung, kidney, prostate, liver cancer, and malignant pleural mesothelioma and discuss the role of periostin isoforms in tumorigenesis and their potential as targets for stroma-targeted anticancer therapy.
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